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We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s4158… 🧵

Chris Lupton and myself as equal co-first authors, study co-led by @Dr_Ellisdon and Dr Michelle L Halls. Monash University Monash Biomedicine Discovery Institute Monash Medicine, Nursing and Health Sciences Monash Research Monash Institute of Pharmaceutical Sciences University of Sydney

Spectacular cryoEM structure of LYCHOS by Charles Bayly-Jones & team out in @nature strongly supports its role as cholesterol sensor for mTORC1 that we (Hijai Regina Shin) discovered, and points to an intriguing mechanism of transport-coupled cholesterol binding. Congratulations!

We are excited to host the incredible Rushika M. Perera at Children’s Research Institute at UT Southwestern! Don't miss her talk on 'Metabolic Dependencies of Metastatic Pancreatic Cancer' this Thursday, Nov 14, from 12–1 pm at NL 12.125.

#ICYMI CRI Director Sean Morrison was honored with ASH's E. Donnall Thomas Lecture & Prize yesterday. Link to #ASH24 feature story ⬇️ cri.utsw.edu/sean-j-morriso… #relentlessdiscovery

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Things I wish more people knew about doing science in the US (thread):

I am beyond thrilled to become a Searle Scholar! Thank you Children’s Research Institute at UT Southwestern, Sean Morrison @RalphDeBerardinis (no longer on X), Roberto Zoncu for all your support and mentorship!

Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction by Mangyu Choe, Denis Titov et al at UC Berkeley dlvr.it/TKF1SB

Excited to share our lab's new paper led by Mangyu Choe where we co-opt UCP as a genetically encoded tool for manipulation of mitochondrial membrane potential. We use this to demonstrate that high ΔΨm drives integrative stress response in response ATP synthase inhibition... 1/2

Very nice work by Denis Titov and Mangyu Choe. I’m so glad this is finally out and that our lab contributed to the story 🥰

I am excited to finally share one of my postdoctoral projects. Denis Titov Hijai Regina Shin - Thank you again for all your support!!

Excited to share the N&V Roberto Zoncu and I wrote for NatureStructMolBiol on the recent surge of LYCHOS structure papers! 🚀 We propose a unifying model that ties together these new discoveries. It’s incredible to see so much momentum building on our work. nature.com/articles/s4159…

The 10 types of clustering that all data scientists need to know. Let's dive in:

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!