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Excited to share: Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging: Cell Stem Cell cell.com/cell-stem-cell… Huge privilege to work colleagues in the lab and with Andy, Stephanie and John

🎉Excited to present our latest work out today nature 1.What gives a leukemia its phenotype – the oncogenic driver or the differentiation stage of the cell-of-origin? 2.Why do RAS mutations always happen late in AML? 3.Who will relapse after VEN? nature.com/articles/s4158…

👉#ASH24 Looking forward to hearing more about the novel #MPNSM findings from Dr Josef Prchal’s Huntsman Cancer Institute group at Late Breaker {#LBA-4}at ASH annual meeting | #NFKB1 #Haplotype | ash.confex.com/ash/2024/webpr… |

Thrilled to share our work on stem cells and #aging in the hematopoietic system! Lots to dig into, and some interesting parallels and distinctions from human #aging and clonal hematopoiesis.

👄👙New cover alert in EMBO Mol. Medicine EMBO Press "Boosting human immunology: Harnessing the potential of immune organoids" by @DirkBaumjohann @BaumjohannLab and #MaximilianMoll. 🏊‍♀️The review article explores recent advances in human tissue-derived immune organoid culture systems

🩸Functional analysis of frequent donor enriched DNMT3A variants examined in CRISPR-edited human HSCs demonstrated their competitive outgrowth potential upon stimulation with #erythropoietin. This study was led by Drs. Darja Karpova and Andreas Trumpp. 🔎 bit.ly/3DJDrMS

No other class of anticancer drug comes close to the number of cures that can be attributed to chemotherapy. Yet, our understanding of how it truly works is extremely limited. This perspective on the topic is a must read. Including for ADC enthusiasts. nature.com/articles/s4156…

🎨 Our Top 5 Cover Illustrations Featured in Cell Press We’re thrilled to showcase five of our favorite cover illustrations selected by Cell Press journals over the years! 🌟Each cover was created in close collaboration with scientists and labs, turning complex scientific

Preventing expansion of DNMT3A-R882-mutant hematopoietic stem/progenitor cells (HSPCs) may avert progression to AML. A new preclinical study in nature suggests metformin may help prevent AML in individuals with DNMT3A mutations by targeting mitochondrial metabolism. UK Biobank

Excited to share our paper out today in Cell Press discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients. authors.elsevier.com/sd/article/S00…

New evidence today NEJM that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…

Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!

Proud of Frontier Medicines showcasing their highly potent and selective p53 Y220C covalent activator at #AACR2025!!

A new study in Nature challenges long-standing views on how Group 3/4 #medulloblastomas develop. Study group led by Prof. S. Pfister argue that large-scale chromosomal alterations, not oncogene mutations, are the earliest events in tumor initiation. 🧵🧵🧵 1/n

Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today Cell Stem Cell !! An amazing collaboration with AK Eisfeld & Elli Papaemmanuil, PhD & Dan Landau !!! Driven by the impressive Maria Sirenko

How it started (undergrad who thinks grant writing is fun🤓) vs how it’s going (A PAPER IN BLOOD🩸!) excited to share the FULL ATF6 story with the world! Thank you to my amazing co-authors and mentor Elf Lab 🇺🇦🏳️‍🌈🏳️‍⚧️⚧️👊🏾👊🏽🌈🟧 for helping my six year long dream come true! ashpublications.org/blood/article/…

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in Nature Genetics 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇