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First single cell ATACseq-based definition of HIV reservoirs ex vivo! Check out Nature Immunology this week. Amazing work by Betts Lab Vincent Wu Laura Vella. Congrats Vincent!!

The single-cell epigenetic, transcriptional, and protein states can now be examined in the same single cell, both for HIV DNA+ cells and HIV RNA+ cells. Congrats to our postdoc Yulong Wei for his amazing late breaker talk at the HIV cure session of the exciting CROI 2023.

Our YaleMicroPath PhD student Kristen Olivera presented her work on spatial transcriptomic profiling of lymph node tissue microenvironment at #CROI2023 as a New Investigator Awardee. Many thanks to Rong Fan's cutting-edge technology and a unique cohort from Thomas Hope Lab!

Feeling excited and humbled being elected as American Society for Clinical Investigation (ASCI) member. Many thanks to generous support from Yale colleagues, collaborators in the HIV field & my students & postdocs who made the scientific discoveries. medicine.yale.edu/news-article/a…

A fun weekend introducing Yale Micro PhD program to new recruits - with amazing current students and faculty! A snapshot of Mario Peña-Hernández 🇲🇽, Mikey Grunst, Ellen Foxman, Maudry Laurent-Rolle, Craig Wilen Benjamin Israelow. Thanks to DGA Dr. Priti Kumar & Registrar Jeni! YaleMicroPath

Congratulations to our outstanding Yale Microbiology PhD student Afeez Sodeinde in the @NathanGrubaugh lab for the NSF GRFP award!! YaleMicroPath Harmit S. Malik

Enjoying stimulating talks with amazing scientists at the REACHforthecure annual meeting. Thank you Brad and Marina for running the exciting collaboratory! Brad marinacaskey Dennis C. Copertino Jr Alberto Bosque 🇪🇸🇺🇸🏳️‍🌈🦠🧬🔬 Rebecca Lynch Guinevere Q. Lee

How scientists run happy hours. YaleMicroPath Rong Fan Thomas Hope Laboratory of Dr. Thomas Hope - NU_CDB, NU_FSM Sizun Jiang

No more labor intensive limiting dilution - Quantitative full-length sequencing of HIV RNA developed by Christian Gallardo Christian Gallardo from the Bruce Torbett lab! Amazing innovative advancement!

Learning HIV life cycle by recapitulating David S. Goodsell 🏳️‍🌈's beautiful and evidence-based illustrations in our lab retreat. Discovered impressive talent of our lab members!

Find & target HIV reservoir, by amazing artist Paco. HIV Science as Art program brings HIV discoveries to life by 12 extraordinary artists living with HIV. On exhibit at MetroArts Brisbane. All funds raised will support community HIV programs & services. bitly.ws/MjVk

Contributing to the exciting #IAS2023 meeting by a Plenary talk on "New Approaches to measuring HIV reservoir" with Asier Saez-Cirion Prof. Thumbi Ndung'u. Enjoyed stimulating discussions with colleagues and friends! Duerr HOPE Group Sharon Lewin @Marinacaskey Alberto Bosque 🇪🇸🇺🇸🏳️‍🌈🦠🧬🔬 Betts Lab

Beautiful study/must read! @RasmiThomas /MHRP today Science Translational Medicine: Single-cell multiomics identified restriction factor PTMA. HIV RNA+ cells overexpress cytotoxic markers. PTMA negatively correlate with HIV RNA. PTMA overexpression inhibits HIV transcription. bitly.ws/PVLN

Understanding heterogenous & rare HIV reservoir requires single-cell multiomics. What are ECCITEseq, FINDseq, PhePseq, ASAPseq, DOGMAseq? Why & how? Principles, method & bioinformatic guide reviewed CO HIV AIDS by our postdocs Michelle Wong & Yulong Wei bitly.ws/Q3Te

Love to explore how HIV hides in CD4 T cells? Love single-cell multiomics, bioinformatics, genomics, and immunology? Wanna join Michelle and Sam, the freshly minted CROI New Investigator Awardees? About to graduate from PhD? Join our lab as a postdoc now! jobs.sciencecareers.org/job/652233/pos…

HIV tat mRNA-lipid nanoparticle+panobinostat can reactivate HIV+ cells 3X higher than PMA/ionomycin (the strongest HIV latency reversing agent) with minimal effects on the cell transcriptome. Congrats Marion Pardons at Linos Vandekerckhove Lab/Ghent! nature.com/articles/s4146…

Enjoying exciting science and stimulating discussions at CROI 2024! Congrats to our postdoc Michelle for her work on finding HIV reservoir and T cell migration dynamics in the gut and undergrad Sam for his work on HIV-host interactions at the integration site.