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Highly recommend you all to check out this new paper from the Alessio Ciulli group with an amazing snapshot of MZ1-targeted BRD4BD2 ubiquination! Great job Charlotte Crowe Centre for Targeted Protein Degradation biorxiv.org/content/10.110…

We welcomed patients and families from the Parkinsons Dundee Research Interest Group to Centre for Targeted Protein Degradation UoD Life Sciences this week. We paired PIs with patients to jointly present work from our labs to each other. Loads of fun and truly inspiring for all involved. #Parkinsons

The Feb 2024 CeTPD journal club issue is now live! buff.ly/3ThU9a7 Thanks to our amazing editors: @liamtommartin92 @krolssimon & Elisha McCrory #openaccess #TPD #journalclub UoD Life Sciences Alessio Ciulli Will Farnaby Andreas holmqvist Aitana de la Cuadra Basté

Humble and proud of receiving this Cancer Research Horizons award on behalf of everyone at Centre for Targeted Protein Degradation UoD Life Sciences and Boehringer Ingelheim who’s made this collaboration possible and contributed to the scientific innovation from the team! In London with Kirsten, Stephanie, Aileen, and Vesna Vetma

Next, our "local CeTPD player" Will Farnaby takes the stage with his talk: "Pursuing Targeted Protein Degradation for Investigating CNS Disease." #TPDFocus 🧠

Will Farnaby is giving a talk on one our cool projects! UoD Life Sciences Centre for Targeted Protein Degradation #TPDFocus

Thrilled to see Nurix Therapeutics's brain-permeable BTK degrader NX-5948 thriving in the clinic! Congrats to the team on their ongoing success! Excited to see how this CNS-active degrader paves the way for other CNS-focused projects! #TPD #CNSResearch ir.nurixtx.com/news-releases/…

The CeTPD May Journal Club issue is now live! buff.ly/3VPRk2p Thanks to our amazing editors: Alessandra Salerno 👩‍🔬 Matylda Izert and Jack Robertson. #openaccess #TPD #journalclub UoD Life Sciences Alessio Ciulli Will Farnaby Andreas holmqvist Aitana de la Cuadra Basté

Lab retreat 2024 is over! Farnaby Group had a fantastic day of scientific discussions and fun activities. Everyone is well-trained in land yachting what is next? UoD Life Sciences Centre for Targeted Protein Degradation

Thrilled to share that, together with my colleagues Centre for Targeted Protein Degradation and collaborators Boehringer Ingelheim, we report Science Magazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/sc…

Mechanistic and structural insights into degrader-targeted protein ubiquitinability, now out in Science Advances! science.org/doi/10.1126/sc… Let's make more degraders that hit the bull's eye 🎯 Alessio Ciulli Centre for Targeted Protein Degradation

The new CeTPD Journal Club issue is live! Catch up with Aug-Sept literature 📰 buff.ly/4eMKUs2 Thanks to our amazing editors: Suzanne O'Connor, Yuting Cao, Kentaro and Kevin Haubrich! #openaccess #TPD #journalclub UoD Life Sciences Alessio Ciulli Farnaby Group

Very excited to see our #CRBN-midi article which we first preprinted last January 👇🏼now published in Nature Communications Kudos to Alena, David and the whole multidisciplinary team at Centre for Targeted Protein Degradation UoD Life Sciences nature.com/articles/s4146…

Funded PhD studentship available to start in Sep '25 working as part of a collab between our lab Centre for Targeted Protein Degradation, Prof Kev Read Drug Discovery Unit and Promega Corporation aiming to establish assays and design rules for induced proximity molecule efflux and brain penetration. sites.dundee.ac.uk/farnaby-group/…

📢 We’re thrilled to share the CeTPD Journal Club Special Edition! Get the details on each speaker’s work, their unique contributions to #TPD, and key takeaways from #CeTPDSymposium2024. buff.ly/4g4pzuc #openaccess #TPD #journalclub UoD Life Sciences (1/41)

The Nov-Jan Journal Club edition is finally here! We have new features, including a section dedicated to papers from CeTPD. Thanks to our editors: Charlotte Crowe, Andreas holmqvist, Jon and María Rodríguez-Ríos #openaccess #TPD #journalclub UoD Life Sciences buff.ly/3EpmffB

Excited to share the Farnaby Group’s first pre-print, detailing our approach to plate-based bifunctional chemical probe discovery, identifying a brain active PROTAC directly from a single screen. 1/7 chemrxiv.org/engage/chemrxi…

New preprint alert 🚨super excited to share our work brain-active chemical probe discovery project I’ve been co-leading with Andreas holmqvist is out. doi.org/10.26434/chemr… For further details check our group account Farnaby Group Centre for Targeted Protein Degradation UoD Life Sciences

So proud to see this out! Hard work truly pays off – give it a read if you haven’t already 🥳👩‍🔬

In our latest blog, we highlight a paper describing the discovery of a #CNS active GSK3 degrader using “orthogonally reactive linkers” and a direct-to-biology approach. lnkd.in/evTqarZi Find out more about #D2B by getting in touch with us via [email protected]