Check out our recent work in Chem : A general N-alkylation platform via copper metallaphotoredox and silyl radical activation of alkyl halides. Congratulations Nate and Albert! doi.org/10.1016/j.chem…

In collaboration with Science At BMS & the Scholes group, we report in Nature Chemistry a site-selective tyrosine bioconjugation, installing a phenoxazine probe for bioorthogonal functionalization. Congratulations Beryl Li, Dan, and everyone involved! nature.com/articles/s4155…

#JustAnotherWednesday

Today in Science Magazine (bit.ly/3F7TcrZ), we report homolytic radical substitution (SH2) as a bioinspired mechanism for sp3-sp3 coupling to form quaternary centers. We envision this strategy will be generally applicable to heteroselective radical-radical couplings.

In 1895, Fischer & Speier reported the now widely-regarded C–O esterification reaction. Today in J. Am. Chem. Soc., we report an orthogonal approach to form C–C bonds. Check it out online: bit.ly/3LqBsLz Congrats Holt Sakai!!

In J. Am. Chem. Soc., we report a platform for red-light photoproximity labeling as we move toward in vivo applications. Congrats to Benito F Buksh, Steve Knutson, James Oakley, @CiaranSeath, collaborators from the Scholes Lab and Alexander Ploss, & the whole team! pubs.acs.org/doi/10.1021/ja…

Very excited & thankful for the opportunity to meet these amazing people, learn more about the cool chemistry happening Corteva Agriscience, and of course get demolished at duckpin bowling 😂 #CortevaScholars2022

Just out on ChemRxiv! We report a strategy to rapidly access diverse 2-substituted bicyclo[1.1.1]pentanes via new HAT and metallaphotoredox methods. Congrats to the Princeton and Merck Boston team! chemrxiv.org/engage/chemrxi…

Thrilled to share our paper on electronic energy migration in microtubules! Now published in ACS Central Science 🤠 🤠🤠 where we made the front cover! pubs.acs.org/doi/10.1021/ac… Authors #GregScholes #RogerPenrose Alfy Benny Funding from Templeton World Charity Foundation (1/n)

Check out our latest work on the late-stage C–H methylation of drug molecules in JACS! Congrats Edna! pubs.acs.org/doi/10.1021/ja…

That moment when you get hooded by a The Nobel Prize winner 🎓 #Princeton23

Doubleheader in JACS! An awesome collaboration with Merck on leveraging μMap toward the mapping of protein binding sites. Congrats Sean Huth Sean Huth, James, @CiaranSeath, Jacob Geri, Aaron, and the whole team at Merck! pubs.acs.org/doi/abs/10.102…

Interested in converting an aliphatic alcohol directly into its bioisostere? Check out our method for deoxydifluoromethylation of alcohols. Congrats to Edna, Nico Cesar Nicolas, and Holt Sakai! Read the full paper out now in J. Am. Chem. Soc.. pubs.acs.org/doi/10.1021/ja…

Last night I was honored to receive the 2025 #BreakthroughPrize in the Life Sciences, reflecting the efforts of many students, collaborators, doctors, and patients in labs around the world. I hope this 4-minute excerpt can inspire when science needs public support more than ever.

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Today in Cell we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10