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#whyscience Day42 Delighted to see our work Hongbo Liu highlighted in ASN Kidney News front page! Next stage is Molecular Nephrology, new diagnostics and new therapeutics for patients with kidney disease. Original paper science.org/doi/10.1126/sc… Comments by Matt Sampson

Nature research paper: Divergent DNA methylation dynamics in marsupial and eutherian embryos go.nature.com/4doxS47

Notice of Short-Term Extension to Early-Stage Investigator (ESI) Eligibility Period grants.nih.gov/grants/guide/n…

At just 16, Mary Sarah became one of the first patients at Golisano Children's Hospital to receive therapeutic hypothermia through a national clinical trial. Now, she’s preparing for college—a powerful reminder of how research can save lives: urmc.info/22K

We are so happy to publish our new foundation model in Nature Methods. we trained OmiCLIP, a vision-omics due modalities model to bridge pathology image and transcriptomic, and Loki, a platform using OmiCLIP as backbone for ST and HE image cross analysis. nature.com/articles/s4159…

Congratulations to Karen Mustian on her ⁦ASCO⁩ award demonstrating her leadership in supportive care. ⁦Wilmot Cancer Institute⁩

This was truly a fun collaboration! Age-related alterations in isoform expression is an underexplored area. The Maragkakis lab tackles this at single-cell resolution.

Joshua's story about living with APOL1-associated diasease inspired Dr. Katalin Susztak to present the connecting bridges from mapping to mechanisms to medicine! 💊 More results at the next #PodocyteConference? 🤩

Judge rules against NIH grant cuts — and calls them discriminatory nature.com/articles/d4158…

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." nature nature.com/articles/s4158…

Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues biorxiv.org/content/10.110… #biorxiv_genomic

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.

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Today, NIH announced a new policy to cap how much publishers can charge NIH-supported scientists to make their work publicly accessible. This reflects our broader effort to restore public trust in public health by creating an open, honest, and transparent research atmosphere.

Nice summary of our paper by Pascal Schlosser and Anna Köttgen ⁦Kidney International kidney-international.org/article/S0085-…

💯 PR for AI-oriented commercial research has now flooded multiple fields: variant effect prediction, perturbation prediction, single-cell integration, AI pathology, to name a few. Unfortunately, this has often led to surreal, incomprehensible papers. Some themes:

The University is now one of only eight Nathan Shock Centers of Excellence in the Basic Biology of Aging by NIH, attracting new researchers to Rochester to explore why some species live longer—and what that means for human health #URochesterResearch uofr.us/4eQCY9J

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state go.nature.com/3IKlcJn

Structural variation in 1,019 diverse humans based on long-read sequencing | ⁦nature⁩ nature.com/articles/s4158…