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So excited to have this work published!!! Thanks Hongyu for your support all the time and the guidance!!

Happy to share a review led by Yuhan Xie on assessing de novo variant effects on birth defects with co-authors Ruoxuan Wu, Hongyu Li, Weilai Dong, and Geyu Zhou. Yale Biostatistics, Yale School of Public Health, Yale School of Medicine link.springer.com/article/10.118…

Wow! Yale Basketball beats Auburn!! Congratulations James Jones Danny Wolf @BezMbeng Matt Knowling August Mahoney Yassine Gharram @JohnPoulakidas Nick Townsend Samson Aletan You’re ALL GREAT! 🙏🏼🏀🙏🏼 from your MedSchool fans at the TAC building!! #LetsGoBuldogs

Thrilled to share our article about our machine learning algorithm that classifies ischemic stroke etiology using electronic health records. Deeply indebted to mentors + collaborators Dr. Lee Schwamm Harlan Krumholz Hooman Kamel LaurenHSansing Kevin Sheth Krishnaswamy Lab Hongyu Zhao

Our paper on immune profiling pts with Fibrotic Hypersensitivity Pneumonitis is out! Cannot thank all of our brilliant collaborators enough! And the biggest thanks to my outstanding mentor Naftali Kaminski! See 🧵 below!

Happy to share the paper led by Zihan Dong on estimating phenotype variance contributed by gene-environmental interactions using GWAS summary statistics, in collaboration with WEI JIANG, Hongyu (Eddie) Li, and Andy DeWan Yale Biostatistics Yale School of Public Health academic.oup.com/bib/article/25…

Another paper led by Jiangnan on joint modeling of human cortical structure through genetic correlation and composite-trait correlation analysis of UK Biobank data, in collaboration with Yiliang Tracy Zhang, Zhaohan, Youshu, Biao, and Yize. Yale Biostatistics Yale School of Public Health sciencedirect.com/science/articl…

Authors Haoyang Li Yingxin Lin Xin Gao Hongyu Zhao present SANTO, a coarse-to-fine method for spatial omics data integration across platforms and modalities. #BiotechNatureComms Nature Communications nature.com/articles/s4146…

Study reports novel models for risk prediction of 8 #cancers (bladder, breast, colorectal, kidney, lung, ovarian, pancreatic, and prostate cancers) in the UK Biobank. Read more here: oxford.ly/3YzfJLk Jiaqi Hu Yixuan Ye Geyu Zhou Hongyu Zhao

Happy to share HBI, a Bayesian method to infer cell-type-specific meQTLs led by Youshu Cheng, together with Dr. Ke Xu and others Yale Biostatistics Yale School of Public Health Yale School of Medicine Yale Psychiatry link.springer.com/article/10.118…

Kudus Amy Zhao Yale MDPhD Program Yale Department of Genetics Yale PCCSM Yale Internal Medicine 👇🏼

We have two great interns, Zhiyuan and Wenxin, who co-lead this project. Thanks to Yuge, Dr. Zhang Le Zhang and Dr. Strittmatter, Yale Neuro Yale Neuroscience for great contribution. Finally, many thanks to Prof. Zhao Hongyu Zhao for his fantastic support.

Nice benchmarking study of 10 different foundation models for single cell data analysis..important best practices, limitations and insights to guide future applications Hongyu Zhao biorxiv.org/content/10.110…

The wait is over: It’s Match Day at Yale School of Medicine! After years of hard work, members of the M.D. Class of 2025 have just discovered where they’ll begin their next chapter as physicians and physician-scientists. With envelopes in hand and excitement in the air,

Excited to share our latest study of the PTSD prefrontal cortex out Genome Medicine. rdcu.be/ejZ3T Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD

In a new Yale University study, researchers led by Matt Girgenti Yale Psychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍 Read More 👇 medicine.yale.edu/news-article/a…

scMODAL is a deep learning framework that leverages known feature links to align single-cell omics. Gefei Wang Hongyu Zhao #data_integration #BiotechNatureComms doi.org/10.1038/s41467…

Very proud of our new #SingleCell work on #PTSD and #MDD out in nature today. Paper: nature.com/articles/s4158… News and views: nature.com/articles/d4158… Press: medicine.yale.edu/news-article/s… Data: doi.org/10.5281/zenodo… Code: github.com/mjgirgenti/PTS…

Huge thanks to all coauthors including Hongyu Zhao JingZhang Mark Gerstein Kristen Brennand. Special thanks to Yale Psychiatry Yale School of Medicine Veterans Affairs for support and funding

Delighted to collaborate with J. Hu and Hongyu Zhao to show that genetic mechanisms leading to a high CAD polygenic risk score are heterogeneous, which may have implications for prevention journals.plos.org/ploscompbiol/a… PLOS Comp Biol