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Congratulations to postdoctoral researcher Bingfei Yu for receiving a Parker Bridge Fellowship. bit.ly/3qLHSN4 Bingfei Yu Howard Chang Parker Institute for Cancer Immunotherapy The V Foundation for Cancer Research

Thrilled to share our paper in Nature Genetics! Cancer cells often amplify oncogenes outside chromosomes. We can now isolate and profile these large circular extrachromosomal DNA (ecDNA) molecules using a method called CRISPR-CATCH. 1/10 nature.com/articles/s4158…

A modular, lentiviral-based display and delivery platform enables decoding of ligand-receptor interactions, receptor-specific genetic cargo delivery, and mapping of receptor specificity and cell states of single cells Howard Chang cell.com/cell/fulltext/…

Happy to share that our work is online Molecular Cell. Our single-cell chromatin atlas of macrophage polarization reveals cyclical macrophage plasticity states in cell cycle. Great collaboration with Julia Belk, Howard Chang & Ansu Satpathy. cell.com/molecular-cell…

Our work on ENTER is finally out Cell! Like📱that can 📷📞🎧, ENTER is a modular viral platform that unifies multiple applications: ⭐️Decode Ligand-Receptor interaction ⭐️Receptor-specific cargo delivery ⭐️Link receptor specificity with cell state at single cell

RIP Christopher T Walsh, a giant of chemical biology. Today Carolyn Bertozzi’s Cancer Breakthroughs seminar at Stanford is dedicated to Walsh and the profound ways in which he influenced and inspired us all.

So when does ecDNA arise, exactly? Our study on #ecDNA and the transformation of pre-cancerous Barrett’s esophagus into cancer is out today. This collaboration brought together @Team_eDyNAmiC, Rebecca Fitzgerald Lab and the @FredHutch Seattle Barrett’s Study.🧵 nature.com/articles/s4158…

Very excited to see our paper with @doudna_lab Jimmie Ye Carl June Howard Chang Nadav Brandes out in Cell !! Obligatory tweet-orial (X-torial??) coming soon... cell.com/cell/fulltext/…

Huge congrats to Jason Buenrostro, who was just named a MacArthur Fellow! Fantastic news!

Delighted to be honored by the King Faisal Prize. I am deeply grateful for all my mentors, collaborators, supporters, and especially lab members former and present. tinyurl.com/yssd6u8b

Excited to share that our paper is out in Cell! We "lnc" Xist ribonuceloproteins (RNPs) to the greater prevalence of autoimmune diseases in biological females. A wonderful multi-institutional collaboration with Howard Chang and many others! cell.com/cell/fulltext/…

Beautiful review article on ecDNA in Nature Reviews Cancer by Howard Chang Mischel Lab !! 🔥🔥👇🏻👇🏻 nature.com/articles/s4156…

“Consensus changing” chemical biology at its finest, a new approach to modulating gene control. Neormorphic covalent ligands redirect the intently studied FOXA1 transcription factor, and instruct on pioneering functionality. A first TF-DNA glue? Way to go Michael Erb and Ben

Bidirectional epigenetic editing reveals hierarchies in gene regulation go.nature.com/4apFU9q

"Pathways for macrophage uptake of cell-free circular RNAs" Read more in Molecular Cell cell.com/molecular-cell… Stanford Medicine Howard Chang

Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…

I am excited to join storied biotech pioneer Amgen 🧪🔬🧬 as Chief Scientific Officer and Head of Research. I look forward to partnering with my new colleagues to deepen understanding of biology and develop solutions to the most pressing medical challenges tinyurl.com/5n86sku5

Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform research into new medical tests, drugs and treatments. Discover more: ukbiobank.ac.uk/learn-more-abo…

Happy to share our paper describing SPACE-seq - a new approach to spatial multiomics and lineage tracing - out today in PNASNews! 🧵(1/5) pnas.org/doi/10.1073/pn…