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New work from Hari Shroff looks gorgeous biorxiv.org/content/10.110…

The Hahn Lab shiqiong hu Timothy Elston @jcherronvfb and colleagues use iPALM microscopy to reveal the “hourglass” shape of the podosome actin core go.nature.com/3zgfWoy

We are thrilled to share a truly exciting discovery by cryo electron tomography: the “hemifusome”- a new cellular organelle complex containing a hemifusion diaphragm! Tavakoli et al. biorxiv.org/content/10.110… Amirrasoul Tavakoli, shiqiong hu and @Becharakachar Tweetorial below (1/8)

Excited to share our new paper Nature Communications - Hemifusomes and interacting proteolipid nanodroplets mediate multi-vesicular body formation. Thank you all for a great collaboration Amirrasoul Tavakoli Seham Ebrahim Bechara Kachar rdcu.be/emtQu

New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do. rdcu.be/emtQu #CryoET #MembraneBiogenesis #Organelle 🧵1/5

4/5 We propose an ESCRT-independent mechanism for intraluminal vesicle and multivesicular body (MVB) formation. Via PND-driven vesicle generation, hemifusion, and internalization, hemifusomes act as hubs for building complex MVBs - no ESCRT machinery required.

5/5 This study rdcu.be/emtQu was made possible by a fantastic team: Amirrasoul Tavakoli and shiqiong hu NIH and Seham Ebrahim UVA