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Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15 pnas.org/content/118/27… Excited to see our highly collaborative work on GDF15 and the hypothalamic pituitary adrenal (HPA) axis appear in PNAS.

Lovely data from Pfizer Inc.. GDF15 appears to contribute to cachexia mainly through its effects to reduce food intake but there are additional food intake-independent changes in skeletal muscle. Looks like glucocortoicoids might be involved, as we predicted in 2021 PMID: 34187898

The Education Committee of the Cancer Cachexia Society Society invites you to our seminar on March 13, 2024 at 12 PM EDT with Danna M. Breen, PhD, Medicine Research Unit at Pfizer, Cambridge, MA, USA. Seminars are open to everyone, please share! See cancercachexiasociety.org to register.

#Cachexia is a life-threatening wasting condition impacting millions of people. It is found in up to 80% of people with advanced cancer and can exacerbate the physical and emotional toll of a cancer diagnosis. Learn more: on.pfizer.com/47lih27

#Cachexia is a little-known condition that can lead to decreased appetite and unintentional weight loss in patients with #cancer. Cachexia can affect patients’ ability to tolerate treatment for their underlying disease. Learn more: on.pfizer.com/3XbylyA.

pfizer.com/news/press-rel…

Happy New Years Eve!

US tops Sweden 3-1 in world junior hockey final cp24.com/sports/us-tops… cp24.com/sports/us-tops…

The majority of the flu viruses identified so far this season have been the H3N2 virus, which typically causes more hosp. & deaths.