1st International Pyrin Workshop in Paris, France Thank you Sophie Georgin-Lavialle, Veronique Hentgen, and Henry Thomas for this brainstorming meeting on an old yet still mysterious innate immune regulator.

Fond memories of 25 yrs ago–working in Dan Kastner's lab (NIH), Ivona Aksentijevich & I found a mutation in TNFRSF1A gene of index case in prototype familial #Hibernian fever (FHF) family. Discovery lead to recognition of #autoinflammatory diseases as distinct group of conditions

Excited to share the first publication from Oda lab in Nature Immunology !! We describe human SHARPIN deficiency as a novel member of 'inborn errors of cell death'. A great collaboration with Dan Kastner, @Bee191961, and Najoua Lalaoui & the LalaLab. rdcu.be/dEx07

In case you wonder whether you should order genetic testing for rheumatic diseases: The pros and cons, managing results and expectations. doi.org/10.1002/art.42…

Review Annual Reviews Hirotsugu Oda Ivona Aksentijevich Alessandro Annibaldi Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases annualreviews.org/content/journa…