🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Join us for the #ProteinScience Symposium IBC Academia Sinica this April in collaboration with JST CREST・さきがけ・ACT-X and JSPS 独立行政法人日本学術振興会（学振）. This event is a must for researchers at all levels from students to experts. Don't miss this chance to advance your research and network with leading scientists!

The deubiquitinase USP45 inhibits #autophagy through #actin regulation by Coronin 1B, say Yuchieh Jay Lin, Guang-Chao Chen, and colleagues IBC Academia Sinica hubs.la/Q03bjMLh0

🔬Publication - by Dr. Chung-I Chang and Meng-Ru Ho Nature Communications This demonstrates that heat shock #protein #LarA can bind to the N-terminal domain of #Lon, and this enables a #leucine residue to bind to LarA, and eventually leads to #proteolysis. doi.org/10.1038/s41467…

🔬Publication - by Dr. Takashi Angata Journal of Biological Chemistry This study demonstrates that the surface #CD22 #protein and its #mRNA are down-regulated in the B cells of #CLL patients, and CD22 #promoter PU.1, Spi-B, and IRF4 are involved in CD22 regulation. doi.org/10.1016/j.jbc.… #leukemia

Publication - by Dr. Guang-Chao Chen Journal of Cell Biology This study demonstrates that #deubiquitinase #dUsp45/#USP45 interact with #Coro1B to modulate #actin structures, thereby regulating #lysosome function. doi.org/10.1083/jcb.20… #biochemistry #biochem #Drosophila #Autophagy

Publication - by danny hsu Elsevier This study showed how the isomerization of #aspartate at different positions of #amyloid β influences the aggregation kinetics and #polymorphism of #Aβ42. doi.org/10.1016/j.jmb.… #biochemistry #protein #misfolding

Publication - by Dr. Hsin-Yung Yen EMBO Mol. Medicine This study showed that inhibition of #PTGR2 prevents #diabetes in mice through metabolizing 15-keto-PGE2 with limited side effects, making it a potential therapeutic target. doi.org/10.1038/s44321… #biochemistry #obesity

2025 #summer #intern program applications are still open! Feel free to contact our PIs if you have any questions. 👉Application deadline: 2025/4/30 👉For more information, please visit: ibc.sinica.edu.tw/SummerInternsh…

Publication - by Dr. Peter Chi and Sheng-Wei Lin Nucleic Acids Res Linear element MRR in fission #yeast assembles phase-separated condensates, with Rec27 directly binds to DNA. This enhances double-strand break during #meiosis. doi.org/10.1093/nar/gk… #biochemistry #biochem #chromosome

🔬Publication - by Dr. Rita P.-Y. Chen, Yung-Shu Kuan, Hsin-Yung Yen, Meng-Ru Ho, and Jung-Kun Wen ACS Publications #Phosphorylation on #tau and #RNA induces liquid-liquid phase separation of tau and lead to subsequent tau #coacervation. doi.org/10.1021/jacs.4… #aggregation

🔬Publication - by Dr. Chun-Hung Lin, Andrew H.-J Wang, and Sheng-Wei Lin Journal of Biological Chemistry FKP catalyzes the conversion from l-fucose to GDP-β-l-fucose. The fucose-1-P and GTP bound separately to the active sites of #fucokinase and #pyrophosphorylase . doi.org/10.1016/j.jbc.… #biochem

🔬Publication - by Dr. Ruey-Hwa Chen Cell Press WDR4 degrades PTPN23, a Bro-1 family #protein, and enhances secretion of multivesicular bodies, thereby potentiating #metastasis and #immune invasion. doi.org/10.1016/j.devc… #biochemistry #cancer

🔬Publication - by Dr. Ching-Ching Yu 日本化学会(BCSJ/ChemLett) This review summarizes #enzymatic #synthesis and #microbial #fermentation for producing #fucosylated human milk #oligosaccharides, and. evaluates approaches for precise synthesis and mass production. doi.org/10.1093/chemle…

🔬Publication - by Dr. Matthias Wolf Nature Communications This study reveals the structure of #bacteriophage φTE and #phage host interactions in #pectobacteria. This may lead to rational design of #biocontrol agents for #plant #pathogens. doi.org/10.1038/s41467… #biochem #Agriculture

[2025 #Summer #Intern Program] We have received more than 100 applications this year and the list of qualified candidates will be announced on May 30. See you in the lab!

🔬Publication - by Dr. Yusuke Nasu Communications Chemistry The newly developed and photocaged MNI-L-lac may be useful for perturbing the concentration of endogenous L-#lactate to investigate L-lactate's roles in metabolic and signaling pathways. doi.org/10.1038/s42004… #biochem #biochemistry

🔬Publication - by Todd L. Lowary This newly developed single-antigen bead #immunoassay for #ABO #antibodies specifically and reproducibly measures #graft-specific anti-A-II antibodies, potentially increasing #transplant access for ABO-B and ABO-O candidates. doi.org/10.1016/j.ajt.…

🔬Publication-by Todd L. Lowary and Dr. Meng-Chiao Ho Cell Press This study reveals the structure and atomic model of #phage #Bxb1, and its structural transition when binding to the #cell surface and transferring #DNA into the #cytoplasm. doi.org/10.1016/j.cell… #biochemistry

🔬Publication - by Dr. Kuen-Phon Wu, danny hsu, Meng-Ru Ho Scientific Reports #hCCL5 forms higher-order #chemokine #filament assemble in high concentration, and the sequence that is essential for #CCL5 trafficking is determined. doi.org/10.1038/s41598… #biochemistry #biochem

🔬Publication - by Dr. Ming-Daw Tsai Nature Communications #HetSIREN is an innovative #deeplearning-based method that can reconstruct or refine #cryoEM volume to get cleaner high-quality volumes and address the most confusing issues in #heterogeneity analysis. doi.org/10.1038/s41467…