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Inferring cell lineages using mtDNA mutations via genomics cell.com/cell/pdf/S0092… Blog: imperialmitochondriacs.blogspot.com/2019/03/lineag…

New paper out - joint forces of IC Mitochondriacs Iain Johnston Payam A. Gammage Minczuk Lab. Thanks for a great collaboration! #mtZFN #mtDNA #PLOSCompBio: Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations dx.plos.org/10.1371/journa…

Check out our latest paper with Iain Johnston in Genetics Society of America: Mitochondrial network state scales mtDNA genetic dynamics genetics.org/content/early/…

Job: Single cell microscopy of mitochondrial DNA – 3 year PDRA between Cambridge Mitochondrial Biology Unit (Chinnery Lab Cambridge Clinical Mitochondrial Research Group in MRC MBU) and Imperial Maths (Jones Lab) bit.ly/2JrFzu0

Check out our blog article with Iain Johnston on the connection between mitochondrial networks and mtDNA genetic dynamics imperialmitochondriacs.blogspot.com/2019/07/mitoch…

Intermediate heteroplasmies can be more expensive than mutant homoplasmy, increasing mtDNA variances can lead to high energy demands, and more! Check out our new paper: journals.plos.org/ploscompbiol/a… and blog: imperialmitochondriacs.blogspot.com/2019/07/energe…

Job between Szabadkai (UCL), Yuneva (Crick), Gammage (Beatson) and Jones (Imperial) groups on In Vivo Oncology and mtDNA therapy jobs.ac.uk/job/BWH694/res…

2 year appointment in Mitochondrial Microscopy between the groups of Patrick Chinnery (Cambridge) and Nick Jones (Imperial) imperial.ac.uk/jobs/descripti…

#12bookstillxmas 1. Favourite first introduction to Bayesian stats. McElreath - Statistical Rethinking xcelab.net/rm/statistical… Richard McElreath 🐈‍⬛ What's yours? #mathscistocking

Our review Visualizing, quantifying, and manipulating mitochondrial DNA in vivo is out jbc.org/content/295/51…

We are looking for a new faculty member in Imperial Biomathematics (area broadly understood) job details are here: imperial.ac.uk/jobs/descripti… Our group is here: imperial.ac.uk/biomathematics… We welcome diverse perspectives and backgrounds!

New Wellcome project on mitochondria and the ageing brain. Three post-docs for up to 5 years each, including two in single cell data analysis with us: imperial.ac.uk/jobs/descripti… Joint with the excellent SpillantiniLab and Chinnery labs MRC MBU

We are excited about a paper in PNAS Ferdinando Insalata: Stochastic survival of the densest and mtDNA clonal expansion in aging pnas.org/doi/full/10.10… We unveil a new evolutionary mechanism quantitatively accounting for mitochondrial mutations expansion in skeletal muscle

Our stochastic model elucidates a mechanism of evolution that can also account for counterintuitive phenomena such as the spread of altruistic strategies. Altruism, apparently disadvantageous, can win thanks to an intriguing stochastic effect that we characterize mathematically.

We predict a clonal wave of advance of mitochondrial mutants, recapitulating experimental observations in skeletal muscle fibres affected by sarcopenia. This new mechanistic understanding allows principled suggestion of therapies that might slow down skeletal muscles aging.

3 year Post-Doc with opportunity to extend by 2 years in the lab of SpillantiniLab joint with our group and that of Patrick Chinnery. jobs.cam.ac.uk/job/38753/ Single cell analysis, mitochondria and Parkinsons.

We Ferdinando Insalata wrote an article explaining our recent PNAS paper with its proposed link between invasive altruists, stochasticity and ageing muscle systems-signals.blogspot.com/2023/02/stocha…

New single cell paper in Cell by @Floklimm and lots of great collaborators Minczuk Lab @JMitophile Mito@GU Patrick Chinnery MathsPrecisionHealth sciencedirect.com/science/articl…

We decided to readvertise our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' 1/6 biorxiv.org/content/10.110…

This pre-print is a game changer for me. Finally, a satisfying and robust answer to the question of where and how mtDNA mutations arise and expand during ageing. Was my pleasure to examine Ali's thesis, on which it is based. Systems and Signals Imperial College Mitochondria Network 🇵🇸 biorxiv.org/content/10.110…