ID Journal Club Really well done trial with great f/u. Kudos to Dr. David B and colleagues and all the study team who I am sure worked tirelessly to make this happen. And to all the patients! #IDJClub

Dr. David B Alice Han Todd McCarty 💊🐉👨‍⚕️ ID Journal Club Agree. I tend to minimally reduce IS. Also cultures in SOT crypto seem to stay positive for longer then the HIV crypto I have seen. #IDJClub

Secondary endpoints 2/3 No difference in re-admissions (individual case details in Table S7, topline results shown below) Reassuring! #IDJClub

Secondary endpoints 3/3 Significantly *fewer* Grade 3 / 4 AEs in the intervention arm (50% vs 62.3%, P<0.001) This was largely driven by anemia in the SOC arm (Is this an adverse effect that is commonly observed in North American patients receiving AMB x 14d? 🤔) #IDJClub

ID Journal Club This is the table that gains you acceptance in the US “healthcare” system! #IDJClub

Let's discuss My impression: This is the largest RCT on CM to date and it was very well done. It definitively answers the Question for which it was designed (Rx of CM in PWH in Africa) Do you agree? #IDJClub

What do you anticipate would be the UPSIDE of using the AMBITION trial regimen in your patients with CM? #IDJClub

What do you anticipate would be the DOWNSIDE of using the AMBITION regimen in your patients with CM? What more would reassure you? #IDJClub

Thank you everyone for a fantastic #IDJClub discussion so far... One for the ages We (@msg_erc x @idjclub) are excited to move this discussion over to Twitter Spaces, starting at 940 EDT (in 3 minutes)... x.com/i/spaces/1OdJr…

x.com/i/spaces/1OdJr…

Miss our #idjclub AMBITION trial Twitter Spaces or just want to hear it again? Here’s the recording, which will be available for 30 days Hear from John Perfect @jobadd Dr. David B @DocWoc71 @KatyGodfrey6 and more… x.com/i/spaces/1OdJr…

Coming to #IDWeek2023? Come hang out at an #IDTwitter meetup! Wednesday Oct 11 ~8 pm til close Westin Boston Seaport District lobby bar Our meetup last year 👇

See yall there, just got another batch of Febrile lanyards!

Please help spread the word!

Thank you to everyone for coming out to our #IDWeek2023 meetup!