🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Nature creates amazing #antibodies, but finding the right ones for any given target is a huge challenge. This paper presents a small but important proof of concept for using #AI to design human antibodies against #antigens of interest (here, #SARSCoV2). biorxiv.org/content/10.110…

The red piece in the image is an antibody that neutralizes multiple HIV-1 strains. It was made in a human. In response to a vaccine. That’s it. That’s the post. Read the paper here: sciencedirect.com/science/articl… Duke Human Vaccine Institute Duke Center for HIV Structural Biology DHVI Structural Biology

Our group has multiple #postdoc openings in the area of #antibody discovery and #vaccine design, both for experimental and computational scientists. Please reach out if interested.

Understanding the fundamental rules of antibody-antigen interactions can lead to transformative new approaches for the development of antibody therapeutics and vaccines against current and emerging viruses. InterestingGamesLab Jason McLellan M. Gordon Joyce journals.asm.org/doi/10.1128/mb…

This manuscript, now including exciting new analysis that helps define quantifiable thresholds on #antigen-specific #antibody public-ness, is now published in mBio: journals.asm.org/doi/10.1128/mb…

IgG3 #antibodies with exceptional breadth of virus cross-reactivity, with no signs of autoreactivity. Work led by Dr. Matt Vukovich, in collaboration with the groups of Priyamvada Acharya, Giuseppe Sautto, Daniel Sheward, and others. dx.plos.org/10.1371/journa…

Check out this paper on broadly reactive IgG3 antibodies led by Matt Vukovich Ivelin Georgiev, Ph.D.. Backstory here is that our collaboration was accelerated by Matt's visit to our lab Duke University under the Duke Center for HIV Structural Biology Trainee Exchange program Duke Center for HIV Structural Biology

This paper is now published in Structure: An exceptionally broad #coronavirus #antibody.

A potently #neutralizing and protective human #antibody with a unique antigenic footprint on #RSV and #hMPV fusion glycoproteins. Collaborative work with Jason McLellan Jarrod Mousa Rachel Bonami James Crowe Robert Carnahan, and others. biorxiv.org/content/10.110…

This manuscript is now published in Bioinformatics Advances: Optimizing #LIBRAseq #antibody-#antigen specificity assignments Negative Binomial Mixture Model for Identification of Noise in Antibody-Antigen Specificity Predictions from Single-Cell Data academic.oup.com/bioinformatics…

Generation of antigen-specific paired heavy-light chain antibody sequences using large language models 1. The study introduces MAGE, a groundbreaking protein large language model (LLM) designed to generate antigen-specific paired heavy and light chain antibody sequences,

Happy to be part of a disruptive project out of my lab. Essentially #ChatGPTForAntibodies — feed in an antigen sequence and it returns an antibody sequence that has a high probability of binding.

Using #antibody sequence alone, can we predict whether two antibodies target overlapping epitopes? A new suite of algorithms developed by vaccine_clint: Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery biorxiv.org/content/10.110…

🧬My new paper is up on bioRxiv! Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery 📄 doi.org/10.1101/2025.0… Ivelin Georgiev, Ph.D. #Immunology #MachineLearning #LIBRAseq 🧵1/5

This work wouldn't have been possible without my PI Ivelin Georgiev, Ph.D. ; our amazing experimentalist alexis ; and the LIBRA-seq data producers Andrea Shiakolas, Ian Setliff, Kelsey Pilewski, and Lauren Walker Hopefully you'll find our methods and models useful! Models drop soon

An ambitious project led by Vanderbilt Health investigators aims to use #AI technologies to generate antibody therapies against any antigen target of interest. Ivelin Georgiev, Ph.D. will serve as the project principal investigator. news.vumc.org/2025/03/10/vum…

SynAbLib: an expandable synthetic library of human paired #antibody sequences. journals.plos.org/ploscompbiol/a…

Fantastic panel discussion with the great Yana Bromberg, Ivelin Georgiev, Ph.D., and Theresa Koehler on the latest advances in #AI for antibiotic discovery and microbiology at ASM #ASMicrobe. Exciting times for science!