Our work is out in Cell Reports (t.ly/nHtgB)! We examine how stromal expression of a STING gain-of-function (GOF) mutation promotes lung inflammation. This study wouldn’t have been possible without co-first author Kristy Chiang. Some highlights from our study:(1/7)

Can an animal sense the world with neurons from another species ? See our brain chimera paper and the accompanying one by Jun Wu mentioned in last post

Angiogenin controls angiogenesis (et plus) by nicking tRNAs. But it’s barely active alone. We discovered how 80S ribosome unlocks Ang’s active site and “brings in” tRNAs. Congrats to Anna Loveland and collab. w/Allan Jacobson! nature.com/articles/s4158…

A newfound cell helps explain why a mouse species is monogamous while its relatives are promiscuous. The findings in nature from our own @bendesky and colleagues may reveal treatments for nurturing-associated conditions such as postpartum depression. zuckermaninstitute.columbia.edu/some-mice-may-…

Thrilled to announce that I will start my lab in the Division of Gastroenterology, Department of Medicine UMass Chan Medical School in October 2024! Stay tuned, will be hiring at all levels for research on how abnormal metabolism and epigenetics contribute to cancer development and immune evasion.

Happy to share our lab’s recent review in Current Opinion Neurobiology on “Microglial phagocytic mechanisms: Development informing disease”. Special Thanks to Becca Beiter and Pat Sheehan in the lab UMass Chan Department of Neurobiology for their hard work on this piece: sciencedirect.com/science/articl…

New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

Excited to share a manuscript out online today nature.com/articles/s4159…, which we had a supporting role for (as Judy Lieberman is NOT). The manuscript found that emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation. A forthcoming synopsis:1/18

Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles coated with the fusogenic FAST protein: Cell cell.com/cell/fulltext/…

Super proud of my mom, Judy Lieberman, and all she has done throughout her wonderful career!

#JustIn: UMass Chan Medical School researcher Victor R. Ambros, PhD, the Silverman Chair in Natural Sciences and professor of molecular medicine, has received the 2024 The Nobel Prize in Physiology or Medicine for the discovery of microRNA. #NobelPrize #medicine #BreakingNews #Worcester UMass Molecular Medicine

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals,

UMass Chan Medical School researcher Victor R. Ambros, PhD, shares the 2024 The Nobel Prize in Physiology or Medicine for his co-discovery of microRNA, single-stranded RNA molecules that play a critical role in post-transcriptional gene regulation: direc.to/mmJ6 #NobelPrize

2024 #NobelPrize laureate in physiology or medicine Victor Ambros was born in 1953 in Hanover, New Hampshire, USA. He is now Silverman Professor of Natural Science at the UMass Chan Medical School, Worcester, MA. umassmed.edu/cancer-center/…

Happy to share our back-to-back papers in nature, presenting a new framework for understanding metabolism - using genomics rather than traditional biochemistry! This led to a systems-level understanding of both metabolic wiring and rewiring. UMass Chan Medical School nature.com/articles/s4158…

Top 5 advances in medicine this week (🧵) 1. Vitamin C modifies the amino acid, lysine, to form VitCyl-lysine This is a novel post-translational modification: it promotes immunity and (in mice!) boosts anti-PD1 immunotherapy to kill cancer Whether vitamin C can also boost

I am thrilled to share our story online at Cell . Big thanks to all authors: Zhiping Weng , Bill, Jeremy Luban , Keith...! authors.elsevier.com/c/1kjdaL7PXu... How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it. #Retrovirus #koala #piRNA More below 👇

Our lab website is up! We are hiring at all levels. dolanlab-tcd.com

I'm psyched to share that my PhD paper is now out in Neuron ! It's also my first paper as both first author and corresponding author, which means even more to me! 🥳 Thank my partner Chi-Chieh Lee for her contribution to the most adorable ever graphic abstract 🥰