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Development of a core outcome set for general intensive care unit patients—A protocol #StrongWork onlinelibrary.wiley.com/doi/10.1111/aa…

adaptr: Adaptive Trial Simulator - new #rstats package for simulating adaptive trials: inceptdk.github.io/adaptr/ Simulates/compares trial designs using adaptive stopping, arm dropping and randomisation. Developed as part of the INCEPT project. Details below: (1/6)

Now also available on CRAN: cran.r-project.org/web/packages/a…

Just published in JOSS: '`adaptr`: an R package for simulating and comparing adaptive clinical trials' doi.org/10.21105/joss.…

We have a paper on our 'adaptr' R-package for adaptive trial simulation and comparison (developed as part of the INCEPT project) published in JOSS joss.theoj.org/papers/10.2110…. The package is documented on a stand-alone website at inceptdk.github.io/adaptr/. (1/6)

This week, the INCEPT programme received the ‘Innovation of the year’-award in the first Danish awards ceremony for clinical trials. We are proud and highly motivated to continue our work on establishing the INCEPT platform trial! Coverage (in Danish): dagensmedicin.dk/syv-glade-vind…

Minor update to the 'adaptr' R package for adaptive trial simulation now available on CRAN (cran.r-project.org/web/packages/a…). Details on the package available below and on inceptdk.github.io/adaptr/. INCEPT @benskov Theis Lange

New paper in Critical Care Medicine: to inform selection and handling of patient-important outcomes other than mortality in INCEPT, we conducted a scoping review summarising selection, definition, and handling of these outcomes in contemporary ICU trials (1/..) doi.org/10.1097/ccm.00…

#causalinference from #ICU #secondarydata could inform and guide critical care #RCTs. But is it used? We're setting out to find out: doi.org/10.1111/aas.14… INCEPT

How are patient-important outcomes other than mortality handled in ICU trials? Anders Granholm et al. call for ⬆️ focus on standardizing outcome choices, adequate handling of missing data and deceased patients in analyses, and use of statistical methods quantifying effect sizes.

Now online in Journal of Clinical Epidemiology (OA): jclinepi.com/article/S0895-… In this manuscript we provide an overview of the key methodological considerations for (multi-arm, multi-stage) clinical trials using adaptive stopping, arm dropping, and randomisation with a worked example. Details below 1/

Version 1.2.0 of the 'adaptr' R package for simulating adaptive clinical trials with adaptive stopping, arm dropping and randomisation on CRAN; details at: inceptdk.github.io/adaptr/ w/ @benskov Theis Lange Aksel KG Jensen INCEPT 1/..

Are days alive without life support/out of hospital (DAWOLS/DAOOH) associated with longer-term health-related quality of life (HRQoL)? We aimed to find out - new article online (OA), doi.org/10.1111/aas.14…, conducted as part of the INCEPT programme. 1/..

New version of our 'adaptr' R package on CRAN including important new functionality (trial calibration) and other improvements - see inceptdk.github.io/adaptr/ and thread below if you're interested in simulation of complex adaptive trial designs. 1/..

Interested in conditional average treatment effects (ie, CATE) to assess HTE in a Bayesian causal framework? Chk out (esp our supp & git page): nature.com/articles/s4159… Co-led by Bryan Blette & Anders Granholm, w/ @msh_manu @AndersPerner Fan Li & some of the INCEPT team.

'The Rise of Adaptive Platform Trials in Critical Care' New ATS Blue Journal led by Ewan Goligher Eddy Fan PRACTICALPlatform w/* @REMAP6 EdinUni_TRAITS INCEPT PANTHER trial @AndersPerner @msh_manu Srinivas Murthy, MD, MHSc Danny McAuley Sarina Sahetya 🔓: doi.org/10.1164/rccm.2… *tagged my best

A step into the future of clinical trials, shaped by the critical care community. PRACTICALPlatform @REMAP6 EdinUni_TRAITS INCEPT PANTHER trial remap-cap @AndersPerner @msh_manu Ewan Goligher Eddy Fan Danny McAuley Srinivas Murthy, MD, MHSc 🔗 bit.ly/3UYrMjF

adaptr #rstats package for simulating complex adaptive trials with adaptive stopping, arm dropping, and randomisation updated to v.1.40 - link and details below. INCEPT

@AndersPerner INCEPT Marie OxenbøllCollet We are so thrilled to receive this award on behalf of all the research panels involved. For the curious reader our core outcome set is now available as a preprint: medrxiv.org/cgi/content/sh…