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We’re hiring a postdoc! Please reach out or share if you know someone interested in studying neurobiology and neurodegeneration as part of an outstanding research environment at Mission Bay. Institute for Neurodegenerative Diseases #dementia #ALS opportunities.ucsf.edu/content/postdo…

Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research! Register here: forms.gle/sqTX5GLNoHiGym…

Excited about our new pre-print - investigating the impact of autism-linked genes on neuronal differentiation. biorxiv.org/content/10.110… Co-led by Willsey Lab Nawei Sun and Kampmann Lab Noam Teyssier & Ruilin（田瑞琳）. Read Noam's tweetorial here:

The Kampmann Lab at UC San Francisco is looking for staff research associates (technicians). Great opportunity to gain research experience for 2 years before applying to grad school! Supportive and diverse training environment. Please RT - thanks! Apply here: sjobs.brassring.com/TGnewUI/Search…

Interested in learning how dyes might help in characterizing protein activity? We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding! go.nature.com/4ajNRNp

Excited to share the work done by Taia Wu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments! onlinelibrary.wiley.com/doi/10.1002/pr…

Are you interested in in vivo #CRISPR screens in mice to uncover mechanisms of #neurodegeneration? 🐭🧬🧠 Apply for this SRA (technician) position in the UC San Francisco Kampmann Lab: sjobs.brassring.com/TGnewUI/Search… Great way to gain research experience before grad school! Please RT/share!

Excited to share our preprint: #CRISPR i-based screen of #Autism Spectrum Disorder risk genes in #microglia uncovers roles of ADNP in microglia endocytosis and uptake of synaptic material biorxiv.org/content/10.110… Read more from first author Olivia Teter below:

Using a novel combination of optical microscopy and cryo-EM, the @SouthworthLab and Condello lab Institute for Neurodegenerative Diseases found that tau filaments from Down syndrome adopt conformations identical to filaments from Alzheimer’s disease. doi.org/10.1186/s40478…

Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins. jbc.org/article/S0021-…

So proud to share this. Nick and the team did fantastic work characterizing of new filament fold of MSA! Along with being our first novel filament structure from the IND, it’s also my first corresponding author paper! biorxiv.org/content/10.110…

In a new paper, researchers from the Condello lab and Prusiner lab Institute for Neurodegenerative Diseases describe the creation and characterization of a novel transgenic rat model to study human tauopathy. link.springer.com/article/10.100…

Most viewed in the last 7 days from JAMA Neurology: Viewpoint describes the evidence for iatrogenic disease based on amyloid-β prions and the possibility that AD has an iatrogenic form wherein amyloid β and tau behave as prions that transmit the disease. ja.ma/3MiEbJO

For its “Conversations with Giants in Medicine” series, Journal of Clinical Investigation interviewed Institute for Neurodegenerative Diseases Director, Dr. Stanley Prusiner. In the interview, Dr. Prusiner discusses his beginnings in science and the path leading to his discovery of prions and the Nobel Prize.

Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs - from ⁦Emma Carroll⁩ ⁦Gestwicki Lab⁩ ⁦Institute for Neurodegenerative Diseases⁩ biorxiv.org/content/10.110…

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP ⁦Gestwicki Lab⁩ ⁦Institute for Neurodegenerative Diseases⁩ nature.com/articles/s4146…

Honored to be part of the first cohort of investigators funded by the Kissick Family Foundation & ⁦Milken Institute⁩ Frontotemporal Dementia research program. #endFTD milkeninstitute.org/content-hub/ne…

Excited to announce new funding from the NIA to investigate the connection between defects in protein homeostasis and neurodegeneration. #FTD #dementia #ALS

🧠 Multiple system atrophy (MSA) is a #neurodegenerative disease with α-#synuclein #amyloid filament accumulation in the brain. This #cryoEM study reveals the structure of a new α-synuclein filament subtype in MSA 🖊 Gergory Merz UC San Francisco & team ➡ bit.ly/40k3q6j

In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to Julie Smeyers and Karen! #ALS actaneurocomms.biomedcentral.com/articles/10.11…