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Access the Final #ICFSR25 Program - Discover our first oral communications. 🔗 frailty-sarcopenia.com/content.aspx?e… @jenel_FA Julian Mutz Yale University King's College London Johns Hopkins University UT Health San Antonio INSPIRE Platform - IHU HealthAge Inserm #AgingResearch #GLP1 #HealthyAging #Frailty

At GHS25 : Bruno Vellas presents #IHUHealthAge & INSPIRE Platform - IHU HealthAge research activities in Toulouse dedicated to geroscience and healthy aging. Isabelle ADER @Restoreinstitut Infinity Toulouse I2MC-Toulouse

A hallmark of aging : "Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells" cell.com/cell-metabolis… Isabelle ADER @restoreinstitut Infinity Toulouse I2MC-Toulouse

Sarcopenia : "Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing." doi.org/10.1186/s12864… Bruno Vellas Rolland Yves Isabelle ADER Infinity Toulouse I2MC-Toulouse

Prediction in China: "Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases." doi.org/10.1038/s42255… Bruno Vellas Isabelle ADER Infinity Toulouse I2MC-Toulouse

Decline in cognitive function : "Brain aging and rejuvenation at single-cell resolution" cell.com/neuron/fulltex… Bruno Vellas Isabelle ADER Infinity Toulouse I2MC-Toulouse Emmanuel G Bautista

Interpretation: "Epigenetic ageing clocks: statistical methods and emerging computational challenges." doi.org/10.1038/s41576… Isabelle ADER Bruno Vellas I2MC-Toulouse Infinity Toulouse Laure Rouch

A future indicator of frailty ? "Skin tactile perception is associated with longitudinal gait performance in middle-aged and older Japanese community dwellers" sciencedirect.com/science/articl… Isabelle ADER Bruno Vellas Infinity Toulouse @restoreinstitut I2MC-Toulouse Penny Wan-Hsuan Lu

Aging clocks : "Somatic mutation as an explanation for epigenetic aging." doi.org/10.1038/s43587… Bruno Vellas Isabelle ADER Infinity Toulouse @restoreinstitut I2MC-Toulouse Laure Rouch

Prolonging healthspan: "Healthy and Unhealthy Aging and the Human Microbiome" go.shr.lc/4hyU8JP Bruno Vellas Isabelle ADER Infinity Toulouse @restoreinstitut I2MC-Toulouse IRSD-Institut de Recherche en Santé Digestive

Dermatology: "Senescence as a Molecular Target in Skin Aging and Disease" sciencedirect.com/science/articl… Bruno Vellas Isabelle ADER Infinity Toulouse I2MC-Toulouse Penny Wan-Hsuan Lu Philipe de Souto Barreto

About functional decline : "Skeletal muscle mitochondrial fragmentation predicts age‐associated decline in physical capacity" onlinelibrary.wiley.com/doi/10.1111/ac… Isabelle ADER Bruno Vellas I2MC-Toulouse Infinity Toulouse Martinez Laurent

Implications on reduced mobility : "Skeletal muscle mitochondrial fragmentation predicts age‐associated decline in physical capacity" onlinelibrary.wiley.com/doi/10.1111/ac… Bruno Vellas Isabelle ADER I2MC-Toulouse Infinity Toulouse Martinez Laurent

The final program for #ICFSR2025 is here! Join 500+ experts in Toulouse or online on March 12-14 to advance research in Geroscience, frailty & sarcopenia. 🔎 Discover the sessions & speakers: frailty-sarcopenia.com/content.aspx?e… Let’s drive innovation for healthy aging together! #Frailty

For the #IHUHealthAge project : "A Novel Blood-Based Epigenetic Clock for Intrinsic Capacity Predicts Mortality and is Associated with Clinical, Immunological and Lifestyle Factors" biorxiv.org/content/10.110… Isabelle ADER Laure Rouch Bruno Vellas CHU de Toulouse - compte inactif I2MC-Toulouse Infinity Toulouse

Decoding immune aging dynamics: "Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination." doi.org/10.1038/s43587… Bruno Vellas Isabelle ADER Cassandra Croucher

RCT description: "Test of Rapamycin in Aging Dogs (TRIAD):....from the Dog Aging Project." doi.org/10.1007/s11357… Bruno Vellas Isabelle ADER Infinity Toulouse I2MC-Toulouse

Biotech Showcase at #ICFSR25 Groundbreaking innovations in geroscience, frailty, sarcopenia, and healthy aging. A unique opportunity to connect with top researchers, industry leaders, and potential investors.

Brain protection in "Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease." doi.org/10.1038/s41586… Infinity Toulouse Bruno Vellas

From geroscience to precision geromedicine: Understanding and managing aging cell.com/cell/fulltext/…