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We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

I’m delighted to be among this year’s recipients of the ERC Starting Grant! This funding will allow my group to take a deep dive into the replication and assembly mechanisms of positive-strand RNA viruses. I'm particularly excited to expand our in situ #cryoET capabilities!

Cryo-EM is a bit of an imaging miracle. We collect 2D images with stupid amounts of noise. We don’t know what we’re looking at, or from which way. Yet some how we can churn it over and get to see (actually see) how life works on molecular scales in 3D. How?

What has AlphaFold3 learned about antibody and nanobody docking, and what remains unsolved? biorxiv.org/content/10.110…

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

Delighted that I could contribute to the #cryoEM validation of these computationally designed antibodies!

Our experience with #alphafold3 🤖 (code recently released) and some of our most recent #cryoEM 🔬 structures (thread below) nature.com/articles/s4158… nature.com/articles/s4146…

Ever wondered how some of the automation in cryo-EM data collection works? Read Bram Koster's 1989 thesis! repository.tudelft.nl/record/uuid:21…

I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of Johan Neyts 💊 Published today in Nature: nature.com/articles/s4158… A huge congrats to everyone involved! 🎉

Proud to be one of the authors of the highest-resolution SARS-CoV-2 #cryoEM entry on EMDB 😄 This came out of a fun collaboration with Bicycle Therapeutics, where we used cryo-EM to validate binding of their biparatopic (EMD-51660) and homotrimeric (EMD-51659) Bicycle molecules🔬

GB-0895, our anti-TSLP monoclonal antibody, has entered a Phase 1 clinical trial for chronic obstructive pulmonary disease (COPD)—its second indication following asthma. Designed using generative optimization, GB-0895 was built for high potency, extended half-life, and targeted

After 6.5 incredible years, this is my final week at Thermo Fisher. It’s been a rewarding journey - working with brilliant people and witnessing the #cryoEM revolution impact drug discovery🔬 Next up: CryoCloud. Excited for what’s ahead!

I'm excited to share our lab's newest publication on the structure and pharmacology of GABA transporter 3 Nature Communications. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. #CryoEM rdcu.be/ei2KY

Our #RNA multimer paper out now in @nature! #cryoEM of 2 distinct nanocages GOLLD and ROOL and membrane-associated OLE. Multimers at ultra-low concentrations, special covariance for cross-molecule kissing loops, and speculation on function nature.com/articles/s4158…. 1/2

Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs Biochemistry & Molecular Biophysics reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online Cell! sciencedirect.com/science/articl…

3rd year running the #UtrechtMarathon 🏃‍♀️ This year feels extra special since I now work right here on campus, where the race starts and finishes! 🏁 ⏱️ Back to the 10k this year (49:18) Well done to my CryoCloud social teammates Robert Englmeier & Thijmen on the half marathon!

Early morning sightseeing jog through Strasbourg with Robert Englmeier 📸 Quiet streets, cathedral views, and a good way to reset before we head into day two of #NovalixConference! Fueled by Alsace cuisine, and maybe a pretzel or two from the welcome reception 🥨 #Novalix2025 #CryoEM

Just published in Nature Communications our new paper integrating #MD and #cryoEM data to construct structural ensembles of complex #RNA macromolecules 🎉✨🥳nature.com/articles/s4146…. Excellent work by Elisa Posani with Giovanni Bussi Max Bonomi ꙮ Pavel Janoš ꙮ N. Toor, D. Haack

Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. biorxiv.org/content/10.110… This #cryoEM study was led by Ruben Hulswit, with key contributions from an amazing team.