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Today Arc Institute releases State, our first perturbation prediction AI model and an important step towards our goal of a virtual cell State is designed to learn how to shift cells between states (e.g. “diseased” to “healthy”) using drugs, cytokines, or genetic perturbations

Online now in GIE’s Articles in Press: "Endoscopy in inflammatory bowel disease: what every endoscopist should know" by Gursimran S. Kochhar and Partha Pal. giejournal.org/article/S0016-… #GITwitter Gursimran Kochhar MD @ParthaP32580643

Interesting 🧵

In Canadian Thoracic Society guidelines, moderate, or low, or very low quality evidence led to conditional recommendations: phac-aspc.gc.ca/tbpc-latb/pubs…

Excellent, excellent paper and moving towards what I have been advocating for years. While I am skeptical of some of the suggested approaches, the fundamental point is spot on, ie that we need to put the puzzle pieces 🧩 together of the wide array of knowns and unknowns and

Second great read today. Many apt observations, including this: “The din and cacophony of researchers barking up the wrong tree sometimes drowned out the news of real progress.”

⭐️I am thrilled to share our review in Gut Journal on #celiac disease and intestinal permeability! We think that the future of CeD prevention and treatment lies in barrier-targeted therapeutics! #MedTwitter #GITwitter #microbiome gut.bmj.com/content/early/…

New research - Development and validation of peripheral blood DNA methylation signatures to predict response to biological therapy in adults with Crohn's disease (EPIC-CD): an epigenome-wide association study thelancet.com/journals/langa… #GITwitter #MedTwitter #IBD

Does Metformin affect outcomes in pts with IBD and type 2 DM? 💊🧐 ✅ Possibly! According to a population based study with >2500 pts and 3 years follow up showing: ⬇️ Use of steroids ⬇️ risk of ✂️ in CD Jessica C. Petrov, MD MSc Gursimran Kochhar MD Jami Kinnucan, MD, FACG, AGAF, FCCF Jana G Hashash, MD, MSc doi.org/10.1093/ibd/iz…

Congratulations to NYU Langone for betting on the perfect combination of skill, passion, intellectual curiosity, and a genuine “desire to make a real difference in the lives of children with IBD”. Few things give me true hope. This does.

Happy to share our findings showing that high UPF is associated with an increased risk of relapse in patients with #CD. #IBD #Diet Prof. Nitsan Maharshak Shira zelber sagi Nutritional Therapy for IBD karger.com/doi/10.1159/00…

Thank you for your work. Please keep going.

The microbiome is knocking on the clinicians' door Gianluca Ianiro, Siew Ng, Giovanni Cammarota, Harry Sokol, Eran Elinav ElinavLab WeersmaLab & colleagues update key microbiome findings ripe to bedside and challenges: loom.ly/gmJBDAE

Alterations to the gut microbiota have been associated with a range of extraintestinal diseases through T cells New findings reveal gut microbiota-specific T cells induce neuroinflammation through molecular mimicry: nature.com/articles/s4158…

Haven’t thought about this in a while but do we have hypotheses about why only a subset (20-40%?) of Crohn’s patients have granulomas?

Dr Mark Silverberg Ildiko ☕️ Changes in phenotypes are so evident that even a single clinician can see them (as we do) in some 10 years (more clearly in 40 years). Not surprising if one knows a bit on biology (some books worth to read below): Cajal’s ideas were right after all

This is very good. I would still personalize, especially for IBD patients who likely require modifications but overall I am always appreciative and supportive of this type pf much needed work.

We’re committed to being a stable funder and champion of promising biomedical research. We invite applications for our Innovator Awards from Aug 1-Sept 30. Grants will support individual and collaborative research that advances the understanding of #IBD. krfoundation.org/news/health/ib…

1/3rd of US teens (>8 million kids) have prediabetes gis.cdc.gov/grasp/diabetes…

Opportunities in collaboration, advocacy, research, and education. YES.