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Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration Nature Neuroscience nature.com/articles/s4159…

NK cells are not T cells. How we target them in immunotherapy strategies must respect this. Some fresh thoughts on this from our team 👇

If you work on cancer, DepMap is a great resource to mine depmap.org/portal/home/#/

Why Dr. Arthur Mortha's lab called @TheOnlyLabEver? Find out in our latest episode, and learn about his work on ILCs and their interactions with the #microbiome! Listen now: bit.ly/4jxanqU

🧵1/ T cells have deservedly been in the🔦for #cancer #immunotherapy, but other engineered cell therapies are now📈. What mediates NK cell exhaustion remains an important unanswered❓. 📄Link: nature.com/articles/s4158… I’m so thrilled🥳to share our work out now🚨nature

How do SSRIs affect #ImmuneCheckpoint blockade? A team at UCLA Microbio, Immunology, & Molecular Genetics showed that inhibiting serotonin transporter enhanced T cell antitumor immunity in mouse syngeneic & human xenograft models. 🖇️ bit.ly/43PS5Ls 🗨️ bit.ly/43x7L7B

Tomomi Yoshida and a team in Dr. Andrew Wang's lab at Yale School of Medicine showed that the subfornical organ in the brain is a nucleus for gut-derived #Tcells! Read the nature paper: go.nature.com/43JMHtC Listen to the discussion on our latest episode: bit.ly/43x7L7B

This week, we talk about bat #organoids! 🦇 Dr. Max Kellner and the @PenningerLab developed respiratory and intestinal organoids that model the #epithelium of the Egyptian fruit bat, the natural reservoir for #Marburg. 🖇️ go.nature.com/3SMQ8KH 🎙️ bit.ly/43x7L7B

How does #acetylcholine affect immune cell development? Researchers at Princess Margaret Cancer Centre showed that cholinergic signaling regulates negative selection in the #thymus. Nature Immunology paper: go.nature.com/45h30Ar Episode: bit.ly/43x7L7B

A new Science #Immunology Review examines the multifaceted ways in which T follicular helper cells modulate immune responses during infection, #allergy, and #autoimmune diseases. scim.ag/3SQqyoq

Dr. Anjali Kusumbe (Anjali Kusumbe) and team delve into the vascular and stromal components of the #TME, their contributions to EMT and resistance mechanisms, and emerging strategies to target these interactions for improved cancer therapy outcomes. 📖 bit.ly/4jSWrrd

A team in Dr. Dan Theodorescu's lab identified how the loss of the Y chromosome in tumors affects cancer outcomes. Read the nature paper: go.nature.com/3I33sbH Listen to the discussion on this week's episode: bit.ly/4n7qA96

Congratulations Prof Laura Mackay who has secured a prestigious Cancer Research Institute Institute (USA) grant to advance research into novel immunotherapy targets for breast cancer. The Mackay Lab is leading the way in tissue-resident memory (TRM) cell research and how these cells can

New in Science Immunology! @EmilyAunins, Dr. Anthony Phan, and their colleagues in the The Drew Weissman Lab and Hunter Lab (ChrisHunter) used lipid nanoparticles encoding IL-12 to boost CD8 T cell responses to mRNA vaccines. 📃 bit.ly/3G24jZL 🎧 bit.ly/4n7qA96

🔥 Weekend Bonus! 🔥 You asked. We listened. Because so many of you needed more time, we’re unlocking 48 extra hours to register at the standard rate for #IUIS2025! 📅 New deadline: Sunday, June 22 — 23:59 CEST 🔗 loom.ly/EFeLN5A #RoadtoVienna

#IUIS2025 is two months away! Join immunologists from around the world and be part of the conversations that will shape tomorrow’s breakthroughs. Learn more: bit.ly/4l1ANlW #RoadToVienna 🇦🇹 International Union of Immunological Societies

🦠 UC Berkeley MCB researchers showed that intratumoral #Listeria monocytogenes can either enhance or inhibit tumor progression. Read the Immunity paper: bit.ly/3TxVPfY Listen to the discussion on this week's episode: bit.ly/4n7qA96

🔬 Discover how the immune system shapes maternal health! Join Yasmine Belkaid, President of Institut Pasteur, as she unpacks the Immune Control of Maternal Physiology at #IUIS2025. 📅 Monday, Aug 18 | 16:15–16:45 🔗 loom.ly/EFeLN5A #RoadToVienna

Dr. Hind Rafei and a team in Dr. Katy Rezvani's (Katy Rezvani, M.D., Ph.D) lab at MD Anderson Cancer Center identified CREM as a therapeutic target to enhance CAR-NK cells. Article: go.nature.com/3G4QJEY Episode: bit.ly/4n7qA96