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📖 The authors elucidate the functional significance of ferroptosis in the pathogenesis of gastric cancer and review the dysregulated metabolic pathways associated with this cell death process. 🔗 bit.ly/402g2hB

🔬 Scientists introduce the high-definition Visium spatial transcriptomic technology and investigate formalin-fixed paraffin-embedded human colorectal cancer samples. Nature Genetics | go.nature.com/4dUvVfL

🔑 Dr. Patrizia Cammareri (Patrizia Cammareri) and investigators identify the chromatin-remodeling enzyme ATRX as a key regulator of colonic lineage fidelity and metastasis in colorectal cancer! nature | go.nature.com/4kVqMGC

Findings from this iScience journal study show that BRAFV600E maintains aberrant DNA and histone methylation patterns in advanced #ColonCancer, likely preserving the transformed phenotype. 🔎 Get the full story here: bit.ly/3HHshKl

Findings from this paper suggest that NUCKS1 contributes to #ColorectalCancer (CRC) invasion and metastasis by stabilizing HDAC2 and activating AKT, highlighting NUCKS1 and HDAC2 as potential therapeutic targets for CRC. 🎯 go.nature.com/462tm9v

Researchers including Drs. Christophe Altier and Joseph Schlessinger identify an ALKAL2/ALK mechanism by which inflammation-responsive nociceptive neurons contribute to #ColorectalCancer progression. | PNASNews 📝 bit.ly/45uG68L

This #ClinicalTrial in Signal Transduction and Targeted Therapy(STTT) assessed the safety and efficacy of garsorasib with or without cetuximab in KRAS G12C-mutated #ColorectalCancer. Read about their findings: go.nature.com/4l7e1ce

Hello? Calling all scientists... 📞 Now is your chance to find out which #organoid you are with a STEMCELL Technologies personality quiz! Share your results and pass it on to your colleagues. bit.ly/3DsbQzT

The latest in #ColorectalCancer (CRC) research! ⚛️ firstascentbio announced a new collaboration with national nonprofit Fight Colorectal Cancer to launch a prospective feasibility study aimed at transforming CRC treatment. 📰 Check out the release: bit.ly/44jvEPo

Can't get enough #IntestinalCell research? Subscribe to our regular newsletter and never miss another update! 💡 bit.ly/4kkWMEu

Scientists summarize the function of p53 and characterize its mutation in colorectal cancer (#CRC), emphasizing the influence of p53 mutation in the pathogenesis of CRC. bit.ly/4kb7352

Investigators showed that PARD6B regulates tumor progression in colorectal cancer (CRC). Its expression in CRC correlates with DNA copy number amplification, including enhancer regions. 🧬 Learn more: bit.ly/3IiEfKw

Huge congratulations to Dr. John Damianos, M.D. and co-authors on their new release in Gut Journal! 👏 Their #Review explores the evidence for increased permeability in #CeliacDisease and the underlying mechanisms. bit.ly/3ZVpl36

This work in Nature Communications led by Dr. Haiyang Chen's team substantiates the role of α-lipoic acid in inhibiting human #IntestinalStemCell aging and presents a potential therapeutic approach for managing age-related human intestinal diseases. 💡 Learn more:

🔎 STK3 was identified as a transcriptional target of YAP1, leading to enhanced DNA repair ability and #stemness acquisition during #GastricCancer progression, report Dr. Wei Kang and colleagues. 📖 Read the findings here: bit.ly/4knTO0X

The #villus length in the small #intestine gradually decreases from the duodenum to the ileum. In a new Nature Communications study, a team of researchers from China investigates the regulatory mechanism underlying this regional disparity. 🔗 go.nature.com/3TrCyNj

A new study shows that MTCH2 deficiency promotes E2F4/TFRC-mediated #ferroptosis and sensitizes #ColorectalCancer liver metastasis to sorafenib. 📖 Read the study: bit.ly/4lMgxoH

A new study has evaluated the efficacy of #sorafenib in combination with the DNA methylation inhibitor #decitabine for the treatment of hepatocellular carcinoma. 🧬 The findings may offer novel therapeutic strategies for clinical management. bit.ly/4lgZhrB

Gastric squamous cell carcinoma (GSCC) is a rare but aggressive subtype of #GastricCancer with unique histopathology. A new study, published in Nature Communications, suggests that loss of EZH2, a histone methyltranferase, promotes GSCC. 🗒️ go.nature.com/4eR3Fve

New work from the lab of Dr. Cristiano Simone has identified SMYD3 as a promising therapeutic target acting directly on c-MYC, with potential implications for countering #ColorectalCancer stem cell proliferation and metastatic dissemination. 📔 Signal Transduction and Targeted Therapy(STTT) 📄