Hope I get through those doors before I leave this amazing institute!

Excited to bring my work across the Atlantic, and take part in the 37th proteinsociety conference. What a way to (almost) conclude a PhD! Cheers from Boston! 😃 EMBL-EBI Cambridge University #Bioinformatics #enzymes #proteins

Proof why one should be thoughtful before blindly applying any clustering algorithm

Thrilled to announce that on Friday 28th July, I successfully passed my PhD viva at Cambridge University! 3.5 joyful years at EMBL-EBI, and the best is yet to come. Cheers!

Our latest work on enzyme active site 3D modularity is out, now published in Journal of Molecular Biology! Check it out in open access here: doi.org/10.1016/j.jmb.… EMBL-EBI EMBL Cambridge University #Bioinformatics #proteins #compbio

Fresh from the oven! 🥧 Our paper on enzyme mechanism space exploration is now online in Nature Methods! Check it out in open access here 👇👇 nature.com/articles/s4159… EMBL-EBI EMBL #bioinformatics #enzymes

Introducing the left-handed DNA helix ladies and gentlemen! 😋😋

Out now: Our new review on the multiple facets of the evolution of enzymes is now available in Biochemical Journal! Check it out in open access!👇👇 doi.org/10.1042/BCJ202… EMBL-EBI #Bioinformatics

This is 50 years of Bioinformatics history, with 3 generations of scientists and associates who have collaborated with, and mentored by Janet Thornton. Thank you everyone who attended this celebration, we hope you enjoyed it as much as we did! Cheers to all and happy holidays!

If you ever pondered why sharks and dolphins look alike while one is a fish 🎣 and the other isn't, then you'll be thrilled to know that our new preprint does not answer that. But it tells you why some unrelated enzymes do the same job. More here 👇 biorxiv.org/content/10.110…

Excited to share my first first-author paper, now live in Bioinformatics Advances! 📚 We assessed 31 cell-type deconvolution methods across five diverse tissues. 🧬academic.oup.com/bioinformatics… #deconvolution #transcriptomics #singlecell

But no one besides Novartis& Lilly etc. has access to the ligand structure prediction. All the data on ligand binding in the paper is irreproducible and should not have been published. As Reviewer #3 for @nature I recommended taking it out and saving it for promotional material.

Ever wondered how many amino acids you can mutate to alanine and AlphaFold2 still predicts same structure? 🤔For denovo design Top7 (1QYS), single-sequence mode, it's 60%. (1/2)

Happy to have contributed to this work within GSK and The Francis Crick Institute!

Always enjoy talking about the enzyme research we did at EMBL-EBI! Big thanks to the European Society of Applied Biocatalysis for inviting me as a speaker at last Friday's webinar, and to the audience that engaged to my work! #Bioinformatics #Enzymes #CompBio

Why are porcupines and hedgehogs spiky while unrelated? 🦔🦔 Sorry, but we don't answer that. But in our new paper in the The FEBS Journal, we explore why some enzymes catalyse the same reaction without an evolutionary link. Check it out here! doi.org/10.1111/febs.1… EMBL-EBI

Festive submission 🎄! We wrote a tool to detect isopeptide bonds in protein structures through geometric template searching! Check out the preprint 👇 biorxiv.org/content/10.110…

Excited to share a key part of my postdoctoral work from The Francis Crick Institute and GSK , published in Nature Communications . A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems. nature.com/articles/s4146…