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A Mechanism for Statin-Induced Susceptibility to Myopathy sciencedirect.com/science/articl…

#PLOSNTDs: Chikungunya virus requires cellular chloride channels for efficient genome replication dx.plos.org/10.1371/journa…

#PLOSCompBio: Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entra ... dx.plos.org/10.1371/journa…

New research posted as a #preprint from our Ion Channel and Membrane Protein structural biology teams Leeds Integrative Membrane Biology

New #ionchannels publication from Leeds researchers Pliotas Group and Jon Lippiat featuring PELDOR/DEER spectroscopy and patch clamp of reconstituted mechanosensitive channels.

We're delighted that Tibor Rohacs is visiting us today. He will be delivering his seminar on "Regulation of TRPM Channels by G-proteins and phosphoinositides" at 2pm in RSLT23.

Very proud to share the first #CryoEM studies by our LICAMM The Astbury Centre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. biorxiv.org/content/10.110…

I am delighted to join the editorial board of The Journal of Physiology (the most prestigious and leading journal on physiology since 1878) as an editorial board fellow. Look forward to working with you Journal of Physiology to serve the whole community.

It's published! #ionchannels #kcnt1 #epilepsy Beth Cole (She/Her) Rachel Johnson Jeff H Dejakaisaya Fishwick Research Stephen Muench

Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels stke.sciencemag.org/content/13/629…

Please to announce my first first author paper is out now in Antiviral Research! Looking at the role of ion channels during the entry of the polyomaviruses SV40 and MCPyV sciencedirect.com/science/articl…

@belab.bsky.social Yue (Mary) Ma Leeds Integrative Membrane Biology Ion Channels @Leeds The Astbury Centre @ScienceLeeds International EPR Society 👋Channelomics.bsky.social👋

Patch-clamp: Long shot; anyone know a patcher in the Liverpool area up for some short term/part time single-channel WORK on a great but easy project!? Even PhD student as part-time casual OK if can patch!! #ionchannels 👋Channelomics.bsky.social👋 Rainbow Lab CVS-UoL Dr Claire Feetham David Colquhoun 🇺🇦 💙

Delighted to share our latest work published today in Cell Reports on how intrinsically rapidly-inactivated PIEZO1 channels sense sustained mechanical force such as blood flow in endothelium. Thanks to our team in Leeds Cardiovascular and Toulouse. cell.com/cell-reports/f…

Another collaboration between Leeds ion channel and virology groups.

Proud that our work on understanding small-molecule modulation of #TRPC channels by #CryoEM has now been published in Communications Biology. Great work driven by David Wright with Dr Katie Simmons Rachel Johnson David Beech Stephen Muench from LICAMM The Astbury Centre @Astbury_BSL. rdcu.be/cbbn1

In our new RSC review we accumulated DEER/PELDOR studies of membrane proteins over 15 years ABC/Multidrug/Secondary transporters, to GPCRs, SEC transloc, Photosynth. & Mitochondr, OMPs, ion channels et al, combined with multiple lipid mimics and MD tools : pubs.rsc.org/en/content/cha…

Congratulations to PhD student Faye Styles on publication of her British Heart Foundation funded research in CDD press nature.com/articles/s4141… We find that ion channel Kv1.3 links cell proliferation to mitochondrial metabolism through a non-conducting mechanism LICAMM Leeds Cardiovascular

Any channel-lovers looking for a job? We have a postdoc position available on a project to characterise our next set of novel KCNT1 potassium channel inhibitors. Deadline 28 April. #KCNT1 #ionchannels #epilepsy jobs.leeds.ac.uk/vacancy.aspx?r…

Upcoming Webinar - Tuesday 29th June at 14.00 BST Jon Lippiat will talk about the discovery of KNa1.1 (KCNT1, SLACK, Slo2.2) channel inhibitors using virtual screening and CryoEM structures. If interested, register here: lnkd.in/e4QmeHA #ionchannels Metrion Biosciences