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Differentiating between benign (BII) and follicular neoplasm (BIV) - spherules vs microfollicles #Thyroid FNA #PathTwitter #patologia #Cytology pubmed.ncbi.nlm.nih.gov/31856389/

Neuroendocrine tumor (NET) grade 3 using Ki-67; in the past neuroendocrine carcinoma/NEC based on the proliferation index. Therapy differs for G3 NET (somatostatin analogues, mTOR inhibitors, alkylating agents, VEGF inhibitors) versus NEC (platinum based). #UMiamiPath

My “CASE of the week” for inhouse cyto signout, illustrating the remarkable phenomenon of how the “bag of polys” are recruited by the “endometrioid endometrial adenocarcinoma”, even at metastatic sites. This case is an abdominal fluid involved by the pt’s known EM CA.

Challenge your #CytoPath #cytology skills. Submit your diagnoses. Then join us in Austin for the Diagnostic Cytology Seminar Michael James Thrall Qiong Gan, MD, PHD Ron Balassanian Florida Man #ASCyto23

Next generation #IHCpath in salivary gland Chinese American Pathologists Association Dr. He (Peter) Wang Very nice summary of ancillary studies that can help in diagnosis

“Like Big Balloons”- Metastatic Esophageal Adenocarcinoma in Pleural Fluid. A pseudokeratotic cell is also noticed (totally nonspecific).

If you like to read final versions - this was just posted: Commentary on SMARCA4-deficient undifferentiated tumors mimicking small cell carcinoma. doi.org/10.1158/1078-0… Original paper by Sutherland Lab and Jin Ng, PhD doi.org/10.1158/1078-0…

Happy to share our new article Molecular and morphologic characterization of intraductal tubulopapillary neoplasms of pancreas with novel potentially targetable fusions kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… Emily Winslow

Cytology case of the week! 30M with 1cm parotid nodule, present for 1year. (Mammaglobin (+), S100 (+), GATA3(+), mucicarmine (-)) Which genetic aberrations will confirm the diagnosis? #pathresidents,GW SMHS,GWPathology, #cytology,#cytopathology,#teachingcytopath,#PathTwitter

When looking at a pilocytic astrocytoma, it's always good to stop and smell the ROSEnthal fibres. #pathology #neuropath #pathtwitter

Broad-based budding

I found these three summary slides from Channing Der on (left) diverse mechanisms of action for KRAS inhibitors & (center, right) acquired genetic mechanisms of resistance to KRASi really useful. #AACRPan24

This is a nice summary of the mechanisms of action of various KRAS inhibitors from Adrienne Cox & Channing Der in their Science Magazine perspective.

FAIRLY easy to find perineural invasion (PNI) in histology of Adenoid Cystic Carcinoma (AdCC). Here is an image from a parotid AdCC with neural tissue caught in the middle of the tumor, most likely reflective of PNI.

Exploring the comprehensive WHO classification of thyroid tumors from the 5th edition! 🔬This detailed chart breaks down the cellular origin, genetic classification, and histological features of various thyroid neoplasms Reference: mdpi.com/2227-9059/12/4…

🧬Cancer types and genes associated with germline mutations 👇 ASCO OncoAlert JCO Precision Oncology #cancer #oncology #genetics #MedX

Glad to announce the publication of our new paper "Molecular Testing for the World Health Organization Classification of Central Nervous System Tumors." Hope people find it helpful! jamanetwork.com/journals/jamao…

"Apoptotic Bodies" are always helpful in the diagnosis of "Small Cell Carcinoma" over a Carcinoid Tumor. (Mediastinal Node, EBUS-FNA)

Brilliant resident from GWU, future cytopathologist Maryam Mehdipour Dalivand Maryam Mehdipour, presenting poster where she integrates molecular pathology and cytopathology #USCAP25 #pathresidents,GW SMHS,GWPathology, #cytology, Cytopathology.org, #TheUSCAP

Today at 8:00am! Don't miss the #USCAP2025 Short Course in Diagnostic Pulmonary Cytology co-presented by Editorial Review Board member Dr. Liron Pantanowitz. His 2024 study describes key approaches to achieving definitive diagnoses: acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn… Liron Pantanowitz