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Lymphotoxin is first inhibitory checkpoint of thymic Treg development that fine-tunes the Foxp3lo Treg precursor pathway by limiting IL-4 availability Magali IRLA Lab Borelli Alexia nature.com/articles/s4146…

Thrilled to announce that our latest research at CIML showing that lymphotoxin acts as an inhibitory checkpoint of thymic Treg development is out in Nature Communications Link: rdcu.be/dSGOW @Irlalab Borelli Alexia Rafa Argüello #Treg #Thymus #Tcells #Immunology

New issue online! This beautiful cover depicts work from Maxim Artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue…

Sex-biased human thymic architecture guides T cell development through spatially defined niches: Developmental Cell cell.com/developmental-…

LAI will host a seminar on Wednesday 16th of October at 11 a.m. in the Amphi 12, Bat B - Cyril Favard (IRIM) "Mechanics and Kinetics of HIV-1 assembly in living T cells: insights from single/few molecule dynamics"

Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0 📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0

Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to

Congrats to Borelli Alexia for successfully defending her PhD thesis at CIML ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in Nature Communications and Cell Mol Life Sci. #Treg #Thymus #Immuno #CIML

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. science.org/doi/10.1126/sc… Science Translational Medicine

A new study on Science Translational Medicine finds RANKL treatment can restore thymic function in aged mice and improve their T cell-mediated immune responses. #aging Jérémy C. Santamaria (PhD) 🇫🇷, Dr.Magali Irla Magali IRLA Lab, Antoine Toubert of Université Paris Cité, et al. science.org/doi/10.1126/sc…

I remember being blown away when Magali IRLA Lab showed me these data CIML 🤯 - Exogenous RANKL substantially reverts thymic involution and improves T cell function in aged mice Science Translational Medicine science.org/doi/10.1126/sc…

New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. Magali IRLA Lab Jérémy C. Santamaria (PhD) 🇫🇷 CIML scim.ag/3ZAqihe

Magali IRLA Lab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in Science Translational Medicine. science.org/doi/10.1126/sc…

Having a great time with the team ! #immunology #CIML