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Fun lunch with my lab’s 4 graduating seniors. We will miss these amazing scientists. Leah is off to an internship at Pfizer, Amanda is off to a tech position with Vanessa Ruta at Rockefeller, Sofia is off to work at a NYC tech startup, and Simon will remain in our lab as a tech.

The moment you've all been waiting for. This year's Juneteenth lecture will be delivered by Dr. Squire Booker! Details 👇🏾 UPenn Dept of Biochem & Biophys Penn Medicine Penn Research Trainee Affairs at Penn Medicine Penn Microbiology Penn IGG

Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs Biochemistry & Molecular Biophysics reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online Cell! sciencedirect.com/science/articl…

Please see this new publication by Arthur Godino, Marine Salery, and others now online in nature. We show opposite roles for D1 vs D2 dopamine receptor- expressing neurons in ventral hippocampus in controlling approach-avoidance behavior. Friedman Brain Institute rdcu.be/ek2DS

exciting time for human pain neuroscience! with the NIH NINDSfunding PRECISION Human Pain Network including Rob Gereau Ted Price director of CAPS at UT Dallas and Weinqin Luo cell.com/neuron/fulltex…

In a STAT opinion piece, our CEO and Director Daphna Shohamy reflects on recent funding cuts for scientists-in-training. She asks, “What am I supposed to say to this generation of young scientists?” Read more: statnews.com/2025/05/07/us-…

Our latest work extends ketamine’s antidepressant action science.org/doi/10.1126/sc… (1/5)

Congrats LomvardasLab and team!

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

Check out our new paper - cover story on Nature Neuroscience - outlining a potential new target for pain treatment and which may explain the susceptibility of older adults to chronic pain

Just finished Natural Neuroscience – a book I think will become an instant classic. This book can for neuroscience what Schrodinger’s ‘What is Life’ did to usher in the golden age of molecular biology. Nachum Ulanovsky gives us a compelling call to arms to understand the brain.

Powerful CRISPR system inserts whole gene into human DNA nature.com/articles/d4158… Many congrats to Sam Sternberg and David Liu for this transformative development. NIH/HHMI funding of basic fundamental science did this! Invest on science!

Thrilled to share our latest preprint and first major project from the lab, where we show a mechanism for direct interoceptive input to the insular cortex. Work by the incredible Zhe Zhao with help from many others including Stefano Berto, PhD

Why create an AI model of a fish? New research from our own Nate Sawtell & Larry Abbott, along w/ Denis Turcu Allen Institute, shows how real fish can use electricity to scan the world, findings that could help us understand our own senses, such as vision. Columbia University

Congrats again Yuki!

Excited to see Jeff Mogil getting an ARM device in his lab for automated and remote mechanical stimulation for use in pre-clinical pain & somatosensation studies.

Congrats to my undergrad student Amanda on graduating yesterday. She even got to bring her family by the lab to see where she's been working. We also recently learned that Amanda has been awarded a Fulbright!