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/ I was honored to accept the 2025 Novo Nordisk Prize from Novo Nordisk Foundation at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of BioInnovation Institute, lunch at Novo Nordisk Foundation, and an evening award celebration and dinner.

I am deeply honored by this recognition but must thank the many postdoctoral fellows and PhD and MD-PhD students in my lab over the years whose creativity and hard work made this possible.

Open-access nature paper from the GIVES-21 consortium, co-led by Siew Ng and I, funded by Helmsley Charitable Trust, and supported by IOIBD, reveals the global evolution of IBD across epidemiologic stages. Co–first authors: Dr. LD & @LingWWindsor nature.com/articles/s4158…

Hats off to the Icahn School of Medicine at Mount Sinai’s Class of 2025! 🎓 Your hard work, resilience, and commitment to making a difference in medicine have led you to this unforgettable moment. Here’s to the bright futures you’re about to shape. #Commencement2025

"Scalable co-sequencing of RNA and DNA from individual nuclei" - cool new method! nature.com/articles/s4159…

Huge congrats to David Stein on a fantastic PhD thesis defense, and for winning the Award for Outstanding Research in Biomedical Science. Truly well deserved!

New online! Functional synonymous mutations and their evolutionary consequences bit.ly/43Dlee0

New online! Genomics of host–microbiome interactions in humans bit.ly/4dIWPHq

SVbyEye: A visual tool to characterize structural variation among whole-genome assemblies academic.oup.com/bioinformatics… 🧬🖥️🧪 github.com/daewoooo/SVbyE…

1/ Today we are proud to feature our former trainee Xiao-Fei Kong – a PhD student (2007-10), postdoc (2010-12) and finally an instructor of clinical investigation at Rockefeller University (2012-15) who is now a physician-scientist and assistant professor at UTSW Internal Medicine

🧬 ChatNT lets you talk to DNA, RNA & proteins My first honest thought was “who needs that? 🤔” turns out it’s built for non-coders 🧑‍🔬 It beats specialist models on 27 tasks and resets the Nucleotide-Transformer benchmark 🏆

I am incredibly sad to learn of the passing of Atul Butte. He was a true giant in our field and a profound inspiration to me and countless others. His vision and contributions have fundamentally shaped biomedical data science. I will miss his boundless energy. RIP my friend.

Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6

Predicting gene expression from DNA sequence using deep learning models.#GeneExpressionPrediction #GenomeSequences #DeepLearning Nature Reviews Genetics nature.com/articles/s4157…

👀 LucaOne: Generalized biological foundation model with unified nucleic acid and protein language nature.com/articles/s4225… 🧬🖥️🧪 github.com/LucaOne/LucaOne

Genome-Wide (GW): an interactive browser for ultrafast chromosome-scale genomics data visualization. nature.com/articles/s4159…

Read it at the Journal of Human Immunity !!

Evolution of splicing model architectures go.nature.com/3I7QBoS Figure from our recent Review: From computational models of the splicing code to regulatory mechanisms and therapeutic implications (free to read here: rdcu.be/dVNV4)

Superb paper by Megan Cooper and colleagues ! Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity rupress.org/jhi/article/1/…