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Patron saint of drug discovery, and I mean this in the best way

This is an interesting mRNA-based approach to achieve tumor-selective targeted protein degradation. Lots of moving parts, which could be a barrier to any kind of clinical translation, but cool proof of concept. pubs.acs.org/doi/10.1021/ja…

Before and after Hurricane Helene

A reminder on why you get higher hit rates from screening small molecules versus large ones. A one thousand member fragment library covers relative chemical space ten million times more than a one million member HTS library.

The recent silence on McConnell's MedChem has broken. Here's my latest post on the real size of medchem atoms. Some are not as big as you think they are while others are larger. mcconnellsmedchem.com/2024/01/11/how…

Northern Lights in Salem CT NBC Connecticut

Protein degraders push into novel target space tinyurl.com/3ptcyzjr Clinic-ready molecular glues and heterobifunctional PROTAC drugs are taking targeted protein degradation into uncharted territory - find out more in this news article

Triply Convergent Ni-Electrocatalytic Assembly of 1,1-diaryl Cyclobutanes, Azetidines, and Oxetanes, appearing today in ChemRxiv :chemrxiv.org/engage/chemrxi… Increasingly complex, three-dimensional leads for drug discovery are testing the limits of modern organic synthesis. In

CANADA WATCHING US NEWS

I voted for her. I think he’s a bad guy. But if you lose the senate, house, electoral college AND popular vote, and you think the lesson is half the country is racist, sexist, homophobic, transphobic, and stupid… wrong lesson. And the same thing will likely happen in 2028.

Podcasts and X were key to this election. In the future, if you want to win, you need to be able to do 2-3 hour long-form podcasts. People don't want cookie-cutter PR-approved sound bites. They want to get to know the real human being. I'll keep doing that with everyone ❤️

Couldn’t agree more

PK/PD modeling of targeted protein degraders: Charting new waters and navigating the shallows sciencedirect.com/science/articl…

Protein Phosphatase 5-Recruiting Chimeras for Accelerating Tau Dephosphorylation | ACS Chemical Biology pubs.acs.org/doi/10.1021/ac…

Google just dropped a 68-page prompt engineering bible 😳 From beginner basics to advanced prompting tactics— It's free, and it’s gold.

When it comes to learning AI & ML, These 10 channels will teach you more than any degrees.

All-in-one AI cheat sheet by Mindstream!! 👉🏻Check this All in one tool: deepagent.abacus.ai/prg x.com/Parul_Gautam7/…

BREAKING: Google just turned Gemini into a full-blown AI school system. Teachers can now assign AI experts to students. Students can auto-generate quizzes and visual explainers. And it's all free in Google Workspace for Education. Here’s what just dropped 👇