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EPIGENETIC HULK HATE PRETENTIOUS NAME! NOT EVEN MAKE SENSE! TABULA IS JUST TABLET! SO WHAT WE LEARN? MANY CELLS EXPRESS THEIR SPECIFIC GENES! OOO SO INSIGHTFUL! WELCOME TO BIOLOGY! SINGLE CELL NO MAKE IT SPECIAL! science.org/doi/10.1126/sc…

Thank you Leukemia & Lymphoma Society Research The Leukemia & Lymphoma Society for being one of our strongest supporters for the past few years! We look forward to bringing newer therapies for patients with MDS/ AML rapidly to the clinic! #leusm #shastrilab Montefiore Health System Albert Einstein College of Medicine - Official

How genes may decode information encoded in the dynamics of activators: cell.com/cell-systems/f…

Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression: Cell Systems cell.com/cell-systems/f…

Albert Einstein College of Medicine - Official Such a treat to be there today to cheer on Maria Aivalioti, Taneisha Sinclair, M.D., Justin Wheat, Josh Weinreb, Richard Piszczatowski MD, PhD, Meng Maxine Tong, and Yu Liu! Congratulations to all the graduates!

Congrats to Uli Steidl Uli Steidl and Amit Verma Amit Verma for an outstanding and inspiring Montefiore-Einstein Presidential Lecture today Albert Einstein College of Medicine - Official Montefiore Health System!

Periodic reminder that talking about how many cells/patients you sequenced in your abstract/tweet is lame. I'd rather hear about what you learned.

The results of different methods applied to the same scRNA-seq data differ substantially. This is true even for fold changes, as shown below for Seurat and Scanpy. The differences between selected transcript "markers" are even larger: biorxiv.org/content/10.110… via @davisjmcc

Excited to share our latest pre-print! Spearheaded by Rayna we show that a microtubule severing enzyme (Fidgetin like 2) that works at the cells leading edge, has its RNAs localized then locally regulated by Igf2bp1/IMP1, tweetorial to come shortly!

Excited to share our preprint by Lauren A Blake and Yang Liu in collaboration with Inoue Lab at JHMI. We established a rapid inducible RNA decay technique and observed rapid recruitment and decay of mRNAs in p-bodies: biorxiv.org/content/10.110….

Curious how chromatin remodeling regulates transcription dynamics in single cells? Now online: nature.com/articles/s4159… A 🧵 1/8

Delighted to have our paper, led by Jorge Diego Martin-Rufino, on conducting massively parallel base editing screens in primary human hematopoietic cells out in Cell today. Can help improve therapeutic approaches for #leukemia and #sicklecell disease: cell.com/cell/fulltext/…

Delighted to announce that I will start as a TT Assistant Professor Emory University SOM in Dept of #Cell Bio & Human #Genetics in Jan 2024. Das lab will take a high-resolution dive into #RNA regulation in #neuronal health and diseases! Will be hiring soon, so please stay tuned.

Major, fatal errors found in the data and methods of a 2020 paper in nature, including millions of reads mis-identified as bacteria. The "cancer microbiome" in this study was simply not there. @abrahamgihawi Mihaela Pertea Yuchen Ge Jen Lu biorxiv.org/content/10.110…

Congrats to Samuel John Taylor on an outstanding talk and discussion at the Northern NYC Heme Club meeting today! EinsteinCellBio EinsteinSCI CDTMI_Einstein Albert Einstein College of Medicine - Official

As #ASH2023 approaches, I wanted to share some ASH abstracts from our MPN cohort Dana-Farber @BrighamHeme now comprising approx 1300 patients on whom we have comprehensive molecular genetic profiling, clinical data, labs and pathology. Three abstracts to follow #MPNsm

Congratulations to Dr. Keisuke Ito Keisuke_Ito_Lab (Old) on his promotion to Full Professor with Tenure (effective July 1, 2023) EinsteinCellBio EinsteinSCI Montefiore Einstein Department of Medicine Albert Einstein College of Medicine - Official! Dr. Ito has expertise in stem cell biology, hematology and oncology, and sickle cell disease.

Marco_Trizzino Lab For the record, it brings me no joy to critique work in a top-line journal that ignores what is by now a large body of literature calling into question the analysis methods used. I do believe that the methods used in our field are important. #methodsmatter 1/

😯 François Jacob (co-discoverer of gene regulation) asked by Lucy Shapiro (Stanford): "It's always been hypothesis-driven research [..] but a new way is looking at vast amounts of data and not asking a question, just seeing if it give you a pattern." Jacob: "It’s very boring.."

Absolutely thrilled to have just matched into the inaugural class of Hematology Track Fellows at MSKCC! Could not be more excited to start the next phase of my training at such a phenomenal institution.