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Hye Jee Hahn, Natalya Pashkova, Michael Cianfrocco, & Lois Weisman @umlifesciences reveal that the vacuole-specific cargo adaptor uses a handhold mechanism to attach to 2 areas on the #myosin-V tail, & suggest that other adaptors use a similar strategy. hubs.ly/Q03mXFQ20

The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria, say Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri and colleagues hubs.la/Q03mdl7C0 #Autophagy

“By identifying & promoting good science, treating authors with decency and respect, and ensuring quality of peer review, editors nurture the reputation and quality of journals.” Read the editorial by our sister journal LifeScienceAlliance's timisstuck: hubs.la/Q03nz3Tn0

Muñoz-Hernández, Xu, Wieczorek et al. report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs hubs.ly/Q03nCNXc0

Claudia Pachinger, Alexander Dammermann et al. (Max Perutz Labs Vienna) present a model for centriolar satellites not as transport modules but as sites of translation specifically of centrosomal and ciliary proteins. hubs.ly/Q03nCM4H0

Good things come in threes: Distinct #Celegans basement membranes utilize novel #collagen IV trimers. Elkie Peebles and Andrea Page-McCaw highlight new work from Srinivasan and colleagues (hubs.la/Q03mM8dQ0) hubs.la/Q03mM99t0

Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair, say Justin Krish Williams, Randy Schekman et al. @ucberkeley hubs.la/Q03mXwv00 #EVs #Exosomes

Excited to present first publication from the Joshi lab, now in Journal of Cell Biology. Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain. rupress.org/jcb/article/22…

Cargo adaptors use a handhold mechanism to engage with #myosin V for #organelle transport, say Hye Jee Hahn, Natalya Pashkova, Michael Cianfrocco, & Lois Weisman @umlifesciences hubs.ly/Q03mXFwQ0 #Microbiology #Organelles #Trafficking

.@joanavferreira, Carvalho et al. show that the integrity of multiple ER membrane contact sites requires Pex30 binding to phosphatidic acid via its dysferlin domain, & that Pex30 activity is regulated by phosphorylation in response to metabolic cues hubs.la/Q03nYGDk0

House, Amit Joshi et al. show that Pex30 dysferlin domain binds PA through its two hydrophobic regions adjacent to beta sheets, & propose that PA, a precursor for neutral lipids, recruits Pex30 at ER subdomains that plays a critical role in LD biogenesis hubs.la/Q03nY5xL0

🚨📢New paper alert! We elucidate the role of Ecdysone Signaling in orchestrating the removal of nurse cells by transforming the epithelial follicle cells to phagocytic fate during late oogenesis. Congrats to all the Authors!!! rupress.org/jcb/article/22…

Ghosh, Prasad et al. IISER Kolkata elucidate the role of ecdysone signaling in orchestrating the removal of nurse cells by transforming the epithelial follicle cells to a phagocytic fate during late #Drosophila #oogenesis. hubs.la/Q03pvtf90 #Development #CellDeath

Train your epithelial cells to become a monster to clean excess Germline cells known as Nurse cell Morphogenesis Lab_IISERK

Our June issue is here! hubs.la/Q03pvJDC0 The cover shows end-on views of the cleavage planes during cytokinesis in one-cell embryos of the nematode #Celegans. From Lebedev et al. of the Zanin lab (hubs.la/Q03pvJGH0).

Ruoxi Wang & Eric Baehrecke discuss the conserved role of Atg9 in #lysosome repair in #Celegans and human cells, in the light of studies by Peng et al in JCB (hubs.la/Q03qy6650) and De Tito et al. in Developmental Cell (hubs.la/Q03qycqG0): hubs.la/Q03qy9qS0

Watanabe, Moriwaki, Matsuda et al. Science Tokyo (Institute of Science Tokyo) combine in silico molecular modeling with cell-free experimental analyses of DJ-1 mutants & present an evidence-based mechanism for DJ-1–mediated cPGA hydrolysis & its significance in #Parkinsons disease hubs.la/Q03qLSHM0

Belyantseva et al report that taperin encircles and stabilizes F-actin at auditory hair cell stereocilia bases and bundles F-actin. Taperin deficiency causes stereocilia disassembly, rootlet breakage at pivots, & other abnormalities culminating in deafness hubs.la/Q03qTLtC0

A study from the #KapoorLab in Journal of Cell Biology provides a model for how different enzymes unfold proteins and remove tags, solving a longstanding mystery about how the two interact. #RockefellerScience rockefeller.edu/news/37824-new…

We're hiring! The Journal of Cell Biology (JCB) seeks Scientific Editor or Senior Scientific Editor, dependent on experience. Join our team in New York City! Apply here 👉 hubs.la/Q03qZh4b0 #STEMjobs #LifeScienceJobs #PublishingJobs #ScienceJobs