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TEN STEPS TO A MARINE TREASURE: Gram-Scale Synthesis of Bipinnatin J – featuring methods that weren't known ≅3 years ago to forge 3 key C–C bonds... Appearing today in ChemRxiv (chemrxiv.org/engage/chemrxi…). Quick Summary: A concise, scalable total synthesis of (–)-Bipinnatin J

Best way to cap off an amazing #ACSSpring2025 meeting. Always feels like home Scripps Research - now with an extended academic family tree!

⌬⌬⌬Heterocycles 2025⌬⌬⌬ Coming on April 7 (see attached syllabus)! This year will be a reverse classroom format wherein all new material will be discussed with problem solving sessions including real-world consulting questions. Aspiring drug hunters and seasoned veterans:

Huge congrats to our very own Bryan Parnitzke for being awarded the NSF Graduate Research Fellowship! We are so proud of you! 🎉🥳 #chemtwitter #nsfgrfp

PDI Cr complexes join the catalyst club for 2+2 cycloaddition between butadiene and ethylene. Congrats to Chirik Group Hanna Hinrika Cramer on amazing work. pubs.acs.org/doi/full/10.10…

We are proud to share our work on a Self-Optimizing, Closed-Loop Electrochemical Platform! Appearing on ChemRxiv today: chemrxiv.org/engage/chemrxi… Highlights of the work below: (1/n)

Just out on ChemRxiv! We report a carbonylative ring expansion of cyclic carboxylic acids via a spin-center shift mechanism. This strategy provides modular access to valuable sp³-rich cyclic scaffolds from readily available carboxylic acids. chemrxiv.org/engage/chemrxi…

Harnessing reduced Fe in electrocatalysis faces many challenges with respect over-reduction and catalyst instability. In this preprint, we describe a redox mediator strategy to tame a (P3P)Fe(I) species for semi-hydrogenation of alkynes as a model study: chemrxiv.org/engage/chemrxi…

Standing on the shoulders of giants, we venture into reduced Fe electrocatalysis enabled by a redox mediator strategy. We are excited to use the lessons learned from this study to develop new forms of reductive Fe electrocatalysis! #chemtwitter #teamFe

SNAr powers the engine of drug discovery and production, but electronic demands restrict access to important chemical space. We describe an e-SNAr strategy to bridge this gap that operates under air at RT with catalytic charge, simplifying scalability. chemrxiv.org/engage/chemrxi…

Another Organometallics Flash Communication! From Chirik Group's Cherish Nie on Ni-promoted ring opening of vinylcyclobutanes. pubs.acs.org/doi/10.1021/ac…

atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in ChemRxiv. 🧐🪞 tinyurl.com/yxyb5rup Amit Kumar Simlandy Turki Alturaifi Peng Liu Group

We say: time to spiro! A fantastic work from Marylise Triacca in collaboration with AstraZeneca: Out in Green Chem: #eSpiro – a metal-free, scalable electrosynthetic route to spiroketals via anodic oxidation. pubs.rsc.org/en/content/art… #OrganoEchem #GreenChem #RealTimeChem

We are grateful to the ACSPRF for funding our proposal on arene functionalization strategies for upconversion of aromatic feedstocks! Congrats to all the awardees this cycle: cen.acs.org/acs-news/ACS-B…

Simplifying Synthesis with Radical Cross-Coupling | drughunters.com/44dDB9V The recording of Phil Baran's (Baran Lab) Flash Talk, "Simplifying Synthesis with Radical Cross-Coupling" is now available on our YouTube Channel. Phil highlights how his group combines

**US-CAN Doctoral Excellence Award Western University -$160,000 to 25 PhD students for up to 4 years. - Must've had offer rescinded/cancelled from US school. -Expedited admission process. -Feel free to reach out, if interested in a PhD in inorganic chem! forbes.com/sites/michaelt…

Calling all organic chemists! Come present in Worcester, MA! acs.org/events/regiona…

This is how you enable uptake of a new method! Hats off to the Knight Chemicals team for making a hydrazides coupling starter kit tailor made for medicinal chemists! Obviously I’m biased since I adore Baran Lab chemistry and the folks that develop it but dang what a product.

Today in Science Magazine, we report a method to replace the C2 of pyridines with N, affording pyridazines. The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter. science.org/doi/10.1126/sc…