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Dual SORT LNPs for multi-organ base editing go.nature.com/3HC9EHt

Now online! Bivalent chromatin instructs lineage specification during hematopoiesis dlvr.it/TLQZkR

A brief guide to statistical analysis of grouped data in preclinical research go.nature.com/4ncNcVJ

Our immune system is incredibly complex. Well suited for A.I. to help deconvolute. NYT Magazine nytimes.com/interactive/20…

🚨Chemo treatment upgrade!🚨 Check out our approach to modernise chemotherapy treatment published today in Nature Genetics. From CNIO Stop Cancer Tailor Bio Cancer Research UK nature.com/articles/s4158… More details 👇

An eye-opener review in Nature Cancer Neoadjuvant immunotherapy is transforming cancer care 🚀! ✅Now proven superior to adjuvant in trials & preclinical studies, it’s SOC in several tumors. 🔝Future focus: combos vs mono, adjuvant after neoadjuvant, & predictive biomarkers

+10 años liderando desde España la generación de conocimiento del papel de #BRCA1 #BRCA2 y otros genes de #HRR en #Cancer #próstata así como al desarrollo de #PARPi en esta enfermedad. Pero a día de hoy misión imposible Dx y tratar adecuadamente a estos pacientes en nuestro SNS

Happy to share our latest #review on #neoadjuvantimmunotherapy: an extensive overview of current and emerging data in NSCLC, TNBC, GI + bladder cancers, melanoma and many more: written with close friends and KOLs published today in Nature Cancer MarleenKokLab doi.org/10.1038/s43018…

How nerve cells transfer their powerhouse mitochondria to fuel cancer cells nature nature.com/articles/d4158… nature.com/articles/s4158…

Mobilizing antigen-presenting mast cells in anti-PD-1-refractory triple-negative breast cancer: a phase 2 trial Nature Medicine nature.com/articles/s4159… nature.com/articles/s4159…

Our favorite cells are always dressing up quite heavily before FACS... we wonder if they enjoy the process 🙈😂 #AcademicTwitter

Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here. adroverlab.com/open-position-…

CRISPR just scored its biggest win yet against Huntington's. The secret? A delivery system called RIDE that sneaks into neurons, makes its edit, then vanishes in 72 hours. Here's what happened 🧵👇

I love the NCBI so much.

Now that we can assay thousands of plasma proteins in 1-2 ml of blood, there's discovery of many new cancer biomarkers nature.com/articles/s4155…

New from the Rouhanifard Lab! What if we could sort single cells based on whether a specific gene was actively being transcribed—and then ask what drives that burst? Introducing: NuclampFISH

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." nature nature.com/articles/s4158…

spectacular paper out in nature describes how red blood cells can seal endothelial leaks and how this can go wrong rdcu.be/euGaz

1/ Why is Ki-67 called Ki-67? And why am I attaching a photo of this beautiful city to the tweet? If you work in pathology or oncology, you’ve likely come across Ki-67 many times. But where does the name come from? A short 🧵 on the origins, function, and significance of Ki-67.

🔥 Primary tumor resection in Stage IV BC? Overall, no OS benefit in JCOG1017 trial, but very interesting results. 👉 Huge benefit in local control 👉Metastatic BC is heterogeneous (e.g. oligometastatic, subtypes, treatments response) Not for all, but an option for some?