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In our new JACC Journals #Advances analysis, we found that 20% of primary care patients Mass General Brigham had a conduction disorder at baseline and another 6% developed a new conduction disorder over 10 years! Mass General Heart #EPeeps #CardioTwitter 📷 Link: bit.ly/3R0bALI

Prior epi studies of cardiac conduction disease have been limited by narrow scope or relied on billing codes/self-report (⬇️sensitivity). Here, we leveraged 4 million #ECGs from 200,000 primary care pts to rigorously define contemporary epi and risk factors for conduction disease

To make sense of a broad scope, we defined conduction disorders by inferred anatomical location of abnormal conduction and presence or absence of AV-node block.

Conduction disorders are common! Nodal and infranodal delay represent the greatest burden. Risk of prevalent and incident conduction disease ⬆️w/ age, and uniformly higher among men (gap narrower at younger ages).

Importantly, traditional #CV risk factors including chronic kidney disease, myocardial infarction, and #afib were associated with future conduction disease. Findings compel prospective studies to assess whether risk factor optimization can ⬇️ conduction dz incidence.

Our findings demonstrate conduction dz is common (esp in older adults) and #CV risk factor profiles may identify individuals at ⬆️ risk. 🙏🙏 Shaan Khurshid, Steve Lubitz, Paolo Di Achille, Victor Nauffal, Chris Reeder, Xin Wang, Jelena Kornej, Emelia J. Benjamin, Puneet Batra, Patrick Ellinor