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Nobel et al. assessed bevacizumab for radiation necrosis post-SRS, showing strong early response and lesion shrinkage. Yet frequent regrowth and limited re-challenge efficacy reflect the challenges of managing RN. #JNO Read more:link.springer.com/article/10.100…

Prof. Brice Ilharreborde from Paris breaks down this week at #SSF @medtronic #medtronic_spine @medtronic_spine Xtant Medical #neurosurgery @randydamico #TumorTalk @jasonsheehanmd @nstumorsection @jneurooncol #neurosurgery #neuroonc #cancer #braintumor

Shen et al. compared PSQ and NGS for MGMT methylation analysis in glioma and found NGS to be more accurate, efficient, and cost-effective. The results support NGS as a strong alternative to current gold-standard methods. #JNO Read more:link.springer.com/article/10.100…

Cerretti et al. Lombardi Giuseppe analyzed bevacizumab dosing in recurrent glioblastoma and found no significant survival or toxicity difference between high and low doses. The findings favor cost-effective lower-dose regimens. #JNO Read more:link.springer.com/article/10.100…

Please read our newest May edition of the JNO! Link: link.springer.com/journal/11060/…

Yun et al. Oncology Division - Geneva University Hospital showed that combining clinical features with peritumoral radiomics from post-treatment MRIs significantly improved prediction of 12-month PFS in glioblastoma (AUC = 0.75). #JNO Read more:link.springer.com/article/10.100…

Tuleasca et al Constantin Tuleasca, MD-PhD, Prof Dr Méd 🇷🇴🇨🇭 Jason Sheehan ISRSy performed a meta-analysis on large vestibular schwannomas treated w/ planned subtotal resection followed by SRS and found high tumor control and excellent facial and cochlear nerve preservation.#JNO Read more:link.springer.com/article/10.100…

Riegel et al. Britta L. Bureau, MD Medical College of Wisconsin analyzed real-world outcomes for newly diagnosed GBM patients treated with or without TTFields and found that TTFields improved OS and PFS, with higher device usage linked to better outcomes. #JNO Read more:link.springer.com/article/10.100…

Our newest issue is now available! #JNO Read more at: link.springer.com/journal/11060/…

Sun et al. Yifei Sun UAB Neurosurgery Dago Estevez, MD PhD evaluated the impact of neighborhood-level deprivation on glioblastoma outcomes and found that higher socioeconomic disadvantage was associated with worse overall survival.#JNO Read more:link.springer.com/article/10.100…

Baxter et al. Blánaid Hicks Queen's University Belfast 🎓 analyzed psychotropic medication use among glioma patients in Denmark, Norway, Sweden, and Wales, finding a sharp increase around diagnosis and sustained elevated use afterward. #JNO Read more:link.springer.com/article/10.100…

Proud to share our latest study! While reoperation at GBM recurrence remains debated, achieving CRET <1cm³ correlates with 46% improved survival vs. partial resection. Standardized volumetric classifications are key to define surgery’s role. Link ⬇️Yoshua Esquenazi, M.D, FAANS Journal of Neuro-Oncology

Fink et al. analyzed cerebral metastases cases in Germany, finding high mortality rates and low palliative care use despite advances in treatment. Results highlight need for improved integration of palliative care and healthcare planning.#JNO Read more:link.springer.com/article/10.100…

Proud to share our new publication in the Journal of Neuro-Oncology! We developed a machine learning-based risk calculator to predict long-term survival in patients with spinal chordoma and chondrosarcoma. #Neurosurgery #AI #SpineTumors #Chordoma #Chondrosarcoma Journal of Neuro-Oncology

Sanvito et al Francesco Sanvito UCLA Radiology characterized post-chemoradition GBM stratified by MRI phenotypes and found distinct perfusion, metabolic, and T2 relaxation feature in tumors with profiles predictive of favorable anti-VEGF response.#JNO Read more:link.springer.com/article/10.100…

New guidelines published in the @JournalofNeuroOncology on the role of imaging for low grade gliomas.

Zschernack et al. highlighted pitfalls in evaluating CDKN2A copy number in meningiomas, showing that MTAP IHC alone can be unreliable. Accurate molecular testing is crucial for accurate grading and informed therapeutic decisions. #JNO Read more:link.springer.com/article/10.100…

Diaz et al. compared acute side effects of proton vs. photon radiotherapy for pediatric medulloblastoma and found similar toxicity profiles, with proton-RT delivering lower doses to intracranial organs at risk. #JNO Read more:link.springer.com/article/10.100…

Lesha et al. analyzed 90-day readmissions after pediatric craniotomy for tumor and identified young age, longer surgical time, high tumor grade, and return to OR as key predictors, with high tumor grade being the strongest factor.#JNO Read more:link.springer.com/article/10.100…

JNO and SSF's Tumor Talk...today was a superb presentation on spinal chordomas. If you missed it, you can still watch it on demand at the Seattle Science Foundation's JNO channel.