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New content online: Arterial and venous thrombosis in systemic and monogenic vasculitis bit.ly/4jGofjg

📣📣📣 A fantastic journey is officially started! First issue of EULAR Rheumatology Open is waiting for you!! 👇👇👇 ero.eular.org EULAR Prof. Gerd-Rüdiger Burmester, MD

🔋 Mitochondrial dysfunction fuels fatigue in #SjögrensDisease ✅ Pan-T cells show ↓ basal, ATP-linked, maximal respiration & reserve capacity ✅ Oxygen consumption rate deficits correlate with fatigue/discomfort scores ✅ Whole-blood mitophagy signature defines discrete

New study on sarcopenia in RA 37.5％ had sarcopenia📝 Associated factors: ⬇️BMI ⬆️disease duration ⬆️joint deformities ⬇️Nutritional score ⬆️CRP Sarcopenia linked to 🔼HAQ and 🔽SF-36 physical function domain. #JCR journals.lww.com/jclinrheum/ful…

Can ChatGPT reliably advise on recombinant zoster vaccination for patients? 📝Study using CDC/ACIP/ACR-based prompts: 🔸Accuracy: 4.04/5 🔸Completeness: 2.3/3 ❌️One major factual error Highlights the need for careful LLMs validation in health care #JCR journals.lww.com/jclinrheum/ful…

Can patient-reported disease activity (PRDA) predict patient-reported disease activity (PRO)? 🔸PRDA shows weak association with PROs 🆕LFA-REAL (PRDA) predicted worse HRQoL, fatigue and work productivity ⇒Supports incorporating PRDA in SLE #JCR journals.lww.com/jclinrheum/ful…

FDG PET/CT supports both diagnosis and management of osseous sarcoidosis. ✔️Identifies optimal biopsy site via FDG uptake ✔️Monitors treatment response through metabolic response 🧐See this image. #JCR journals.lww.com/jclinrheum/ful…

Striking subcutaneous edema in anti-NXP2 positive dermatomyositis. Don't miss the images showing pre- and post-treatment changes. journals.lww.com/jclinrheum/ful…

🌍Global survey on SSc-ILD treatment shows: 💊 MMF is 1st-line in 92% 💉 RTX/TCZ used 2nd/3rd line 💊 57% add antifibrotic after initial failure ➕Combination therapy (RTX+ MMF, MMF+TCZ) less common 💊 Prednisone still common (36%) #Rheumatology #JCR journals.lww.com/jclinrheum/abs…

US Real-world treatment for Raynaud phenomenon (RP): ✔️ CCBs remain 1st but declining ✔️ PDE5i increasing 🥲PDE5i/ERA/PGA: used in just 15% 😰 Only 29% had persistent medication use 📝Community rheumatologist need better guidance to manage SSc-RP #JCR journals.lww.com/jclinrheum/ful…

Aspiration-negative gout?🤔 DECT can still detect MSU crystal deposits❗ Don't miss the case📝 #JCR journals.lww.com/jclinrheum/ful…

🆕JAK inhibitors may offer a new option for refractory mucocutaneous Behçet disease. See the remarkable improvement of oral aphthous ulcers👄 and erythema nodosum after upadacitinib❗️ #JCR journals.lww.com/jclinrheum/ful…

A new study reveals high rates of depression in PMR🔥 🔺Up to 25% had depression at baseline 🔻Poor physical function (HAQ-DI) was the strongest predicter ⏩️Highlights the need to address comorbid depression #JCR journals.lww.com/jclinrheum/ful…

🚨 New research alert! 🚨 In SSc, early predictors of persistent disease activity include: • ESR↑ • Medsger Severity Scale • Baseline SCTC-DI Moderate-severe damage linked to ILD, PAH, cardiac & diffuse SSc. 🔍 Read &RT journals.lww.com/jclinrheum/abs…

Do polymorphisms methionine synthase reductase (MTRR) 66 A/G & synthase (MTR) 2756 A/G influence MTX response in RA? 🧬 Meta-analysis (8 studies): • No link wt 66A/G, 2756A/G • BUT: Larger studies (n≥150) → better MTX response in GG+GA 📖Read & RT!! journals.lww.com/jclinrheum/abs…

💡 How are global experts treating SSc-ILD in 2024? Survey says: • MMF = 1st-line for 92% • RTX or TCZ often 2nd/3rd-line • 57% add antifibrotic if needed • MMF+RTX = most used combo ⚠️ Prednisone >20mg used by 12%—more than expected. 🔍 Read & RT journals.lww.com/jclinrheum/abs…

🌍 How do global guidelines tackle PsA? New review compares ACR, EULAR, BSR, GRAPPA & PANLAR: 📌 All agree: Treat-to-target 🔄 Differences in: • Biologic/tsDMARD sequencing • Enthesitis & dactylitis management • Comorbidity integration 🔍 Read&RT journals.lww.com/jclinrheum/abs…

🧊 How is Raynaud managed in US SSc patients? 📊 From 270 patients: • Only 61% received RP meds • CCBs most common (48%) but declining • PDE5i use rising • Maintenance & combo therapy = low 💵 Socioeconomic status influenced treatment 🔍 Read & RT journals.lww.com/jclinrheum/abs…

🚨 New in #Lupus research! 🚨 📚 A comprehensive review of ANA-negative SLE 🔍 21 studies (n=152) 🌞 Most common features: skin, photosensitivity, arthritis 🔬Top autoantibodies: anti-SSA/Ro, anti-dsDNA #RheumTwitter #Autoimmunity #Lupus #JCR share.google/hjEa6OgAbNDqOW…