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Did you present research at #IMMUNOLOGY2025™? If so, The JI invites you to submit manuscripts based on your abstract for a special collection “Highlights of IMMUNOLOGY2025”! Expand your conference presentation and widely share your findings! Learn more: ow.ly/1Cj550WbZcv

A Translating Immunology article re-evaluates B cell depletion strategies, providing an alternative explanation for why CD19 depletion may be effective at achieving complete and durable remission in autoantibody-positive autoimmune diseases. Read more: ow.ly/3XFy50WbZkr

Modifying IFN-gamma secretion holds therapeutic potential for various conditions. A new #BriefReview explores the mechanisms through which metabolic changes influence altered IFN-γ synthesis by immune cells, examining therapeutic possibilities. Read more: ow.ly/h1ji50WbZnF.

The June issue of The JI is online now! Find cutting-edge research, reviews, and commentaries on your favorite immunology topics. Read everything now: ow.ly/cVNx50WiiAe

Dr. Otto O. Yang, Professor UCLA, provides a review of lessons learned in the five years since #COVID19 was identified. Read what research has revealed and what remains to be investigated: ow.ly/XQo950WiiBT

A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: ow.ly/gBgR50WiiCr.

June #TopRead from UAlberta Med & Dent and Women & Children's Health Research Institute found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm

A June #TopRead from Pathobiology Graduate Program at Brown University and Brown Research uncovered an unanticipated role for pulmonary conventional NK cells in preventing viral dissemination from infected lungs when studying murine cytomegalovirus. Read about the findings in The JI: ow.ly/ml7550WiiJY.

This June #TopRead found heme interaction with HIV-1 and influenza virus bNAbs enhanced their intrinsic poly-reactivity, without altering HIV-1 binding and neutralization, contributing to a better understanding of the molecular properties of HIV-1-bNAbs ow.ly/EAVw50Wijt2.

Final June #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.

Data revealed that inducible co-stimulator (ICOS) mediates antitumor immunity by promoting the secretion of cancer-suppressive cytokines, suggesting that activation of ICOS may be a potential therapeutic strategy for #colorectalcancer. Read more: ow.ly/vp4e50WlLvu.

Researchers characterized the transcriptional and chromatin accessibility landscapes of bone marrow and splenic hematopoietic progenitors in breast cancer to understand the hematopoietic consequences of cancer. Read more: ow.ly/gfEZ50WlLzk.

Researchers have found evidence that S100A10 is critical for monocyte mobilization, suggesting that targeting the S100A10-CCR2 pathway may be an attractive approach to regulate inflammatory responses and infectious diseases. Read about it in The JI: ow.ly/npiu50WlLJi.

Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: ow.ly/xjnl50WlNLa

Researchers investigated the role of follicular dendritic cells (FDC) and the protein WDFY1 in systemic lupus erythematosus to understand the mechanisms by which FDCs engage autoreactive B cells. Learn more about their findings in The JI: ow.ly/Qm0a50WlNOy.

In a new #CuttingEdge article, data show that the transcription factor Batf3 promotes the development of CD4+ resident memory T cells and thus contributes to allergic responses to inhaled allergens like #asthma. Learn more in The JI: ow.ly/Aj3050WlNRf.

Data suggest that the NLRP3 inflammasome engages an additional innate immune lytic cell death pathway, PANoptosis, for cell death beyond the early timepoints of innate immune responses, which may lead to new therapeutic targets. Learn more: ow.ly/ZkJy50WlNT1.

In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: ow.ly/IVtu50WlKRA.

#ICYMI: Researchers shared the development of an assay for quantitative assessment by flow cytometry of selective inhibitor effects on peptide trimming, both in the endogenous MHC-I processing pathway and in cross-presentation. Learn more in The JI: ow.ly/9V6M50WnBq8.