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PAPER OUT !! 🎉🥂🍾 @nature nature.com/articles/s4158… Viral restrictor APOBEC3A is a major cause of mutational signatures found in >50% of cancers + more, Tweetorial👇 With John Maciejowski Via WGS/251 cancer clones (available!) Broad Institute Memorial Sloan Kettering Cancer Center Wellcome Sanger Institute

Our new paper is online nature! Anti-viral A3A enzyme causes cancer mutations. nature.com/articles/s4158… Led by Mia Petljak w/ @ALLIEgator__, Kevan Chu, ErikBergstrom (Alexandrov Lab) and others. 🙏 to National Cancer Institute, The Pew Trusts. Memorial Sloan Kettering Cancer Center Broad Institute Wellcome Sanger Institute

Fascinating new study from Memorial Sloan Kettering Cancer Center’s Sloan Kettering Institute molecular biologist John Maciejowski, Sheds Light on How a Natural Defense Against Viruses Can Lead to Mutations in Cancer Cells mskcc.org/news/ski-study…

DNA damage and somatic mutations engraved on the genomes of mammalian cells after irradiation with a nail polish dryer biorxiv.org/content/10.110…

The Scientist spoke to the awesome Mia Petljak about our recent paper and speculated about the potential implications! Underdog Enzyme Likely Responsible for Mutations in Most Cancers the-scientist.com/news-opinion/u…

One of the best things about lab is working with great scientists like Eleonore Toufektchan!

Check out our piece Nature Genetics 👇🥳 Addressing the mechanistic gaps & strategies forward to investigate the full therapeutic potential & benefits of inhibiting APOBEC mutagenesis in cancer Fab collab 🙏 Weitzman Lab Abby Green John Maciejowski nature.com/articles/s4158…

Really cool new work from de Lange lab: Telomerase adds telomeric repeats to DSBs to generate functional neotelomeres. Potential path out for BFB cycles? biorxiv.org/content/10.110…

New methods chapter with 𝐚𝐥𝐥𝐲 to describe the isolation and use of monoclonal antibodies with specificity for APOBEC3A and the APOBEC3A/APOBEC3B/APOBEC3G proteins! authors.elsevier.com/a/1g66Q,25QIk-…

Ever noticed that #CRISPR HDR is great in some cells but terrible in others? Even editing the same site. Superstar postdoc Erman Karasu figured out why! TREX1 is a biomarker for HDR: TREX1-low = high HDR and TREX1-high = low HDR. Also designed an easy fix! biorxiv.org/content/10.110…

We are hiring - postdoc positions available! If you are interested in joining a highly collaborative and supportive team to study immune tolerance, host-microbiota interactions and early life immunity, see link below for details! Please RT! thebrownlaboratory.com/contact

Exciting news - the Petljak lab is starting this summer NYU Grossman School of Medicine 🎊👩🏼‍🔬 Delving into the causes & impacts of somatic mosaicism in cancer & aging tissues w exp & comp omics 🧫💻 !part of bold new Cancer Genomics Program Marcin Imieliński, driving genomics->the clinic Hiring soon 🤗

1/ Our paper identifying #Chromosomal_Instability as a new driver of #epigenetic abnormalities in #cancer is out @nature nature.com/articles/s4158…

POSTDOCTORAL POSITIONS AVAILABLE to study how human DNA replication acts both as a genome stabilizer and, when corrupted, as a genome destabilizer, using in vitro systems reconstituted with human replication proteins. For more information please see externaltalent-mskcc.icims.com/jobs/69452/pos…

Our latest work on engineering extrachromosomal circular DNAs (ecDNAs) is now available in biorxiv. In this preprint we describe a novel strategy to engineer the formation of large (>1 Mb), multigenic, amplifications mediated by ecDNAs in cells and mice. biorxiv.org/content/10.110…

We are live NYU Grossman School of Medicine ! petljaklab.com 🧫💻 Looking for exper. & comp. staff,postdocs,trainees 🧬 To delve w us into the somatic mosaicism in cancer & aging 🌇 In CURE facilities in the heart of Manhattan cure.345pas.com 📧 [email protected]

Congratulations to Eleonore Toufektchan and all co-authors on our new study showing how TREX1 guards against anti tumor immunity by degrading cytosolic DNA to limit cGAS-STING! Great collaboration with the Samuel Bakhoum lab.

A lot of fun to highlight great work from Giuseppe Leuzzi and Alberto Ciccia et al showing how the the DNA translocase SMARCAL1 dampens immune responses against tumor cells through two distinct mechanisms. Together with Eleonore Toufektchan in Molecular Cell. authors.elsevier.com/a/1ijJ1_Oylrla…

Excited to share my latest work from the @MarraffiniLab, in collaboration with Phoebe Rice, now online nature!! nature.com/articles/s4158… We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria! A thread 🧵: 1/

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…