Is it time to re-think to the implications of obesity/IR in chronic hepatitis & to their influence on HCC metabolism? Can recent discoveries in the NASH/NASH-HCC fields be exploited to other liver disease? With Jack Leslie & Derek A Mann, We think so! Check it out on Journal of Hepatology

Happy to share a preprint of our work on neutrophils and their role in NASH-HCC immunotherapy. Derek A Mann Owen Sansom 🏳️‍🌈 Leo M. Carlin Cancer Research UK

check out the latest issue of Nature Reviews Gastroenterology & Hepatology with a review from #hcchunter researchers Jack Leslie, Derek A Mann and others about #neutrophils in #HCC featuring on the front cover! 👇

Metabolic disturbances caused by #HCV ➡️can persist after successful treatment ➡️can be a risk for development of #LiverCancer 🔓#OpenAccess at👉bit.ly/3JHBjmr Fibrosis Lab Jack Leslie Derek A Mann Michele #LiverTwitter

Metabolic disturbances caused by #HCV ➡️can persist after successful treatment ➡️can be a risk for development of #LiverCancer 🔓#OpenAccess at👉bit.ly/3JHBjmr Fibrosis Lab Jack Leslie Derek A Mann Michele #LiverTwitter

#GUTImage from the paper "Immature neutrophils bring anti-PD-1 therapy in NASH-HCC to maturity" via bit.ly/3qBU4jx #LiverTwitter #NASH #HCC

If you’d like to read the final version of our work on GALNT7 mediated glycosylation in prostate cancer you can find it here 👇🏻 Jennifer Munkley ProstateUK Profs #glycotime nature.com/articles/s4138…

📢 Job Alert🚨Research Associate in Computational Immunology: checkpoint pathways, macrophages and immune dysregulation in liver inflammation📢 Join our Liver Immunology Group at Metabolism, Digestion & Reproduction | Funding: MRC NIRG | Collaborators: Prakash Ramachandran, MarkMcPhail, Penny |

Check out a research highlight on our work on GALNT7 in prostate cancer Nature Reviews Urology nature.com/articles/s4158…

Excited to share our Review entitled “Harnessing neutrophil plasticity for HCC immunotherapy”, with a pan-cancer functional correlation of neutrophil subtypes and the latest neutrophil therapies in cancer! Jack Leslie Fibrosis Lab Portland Press Link 👉 portlandpress.com/essaysbiochem/…

𝐓𝐡𝐞 𝐞𝐱𝐞𝐫𝐜𝐢𝐬𝐞 𝐈𝐋-𝟔 𝐞𝐧𝐢𝐠𝐦𝐚 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 How can a molecule released during exercise be linked to cancer? Derek A Mann, Jack Leslie, Mark Ross, Ph.D, Henning Wackerhage and I came together to address this question Full text Trends in Endocrinology & Metabolism sciencedirect.com/science/articl…

Our research topic "Myeloid cells in health and liver disease" Jack Leslie Carsten Deppermann (Frontiers - Immunology) is still open for submissions - #livertwitter see more information and published articles below: frontiersin.org/researchtopic/…

Leslie J et al. c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis #LiverTwitter shorturl.at/lLTX9

Funded DiMeN DTP PhD position available in our group! Working at Newcastle University Centre for Cancer and University of York. If you’re interested in glycobiology, prostate cancer or tumour immunology please get in touch and think about applying! @NUBiosciences ProstateUK Profs #glycotime findaphd.com/phds/project/f…

Fully funded PhD studentship at Newcastle University funded by NIHR Newcastle BRC Come and use large data and computational analyses to find out how cancer associated fibroblasts orchestrate immunosuppression in liver cancer Fibrosis Lab Helen Reeves findaphd.com/phds/project/p…

We are looking for a postdoc to join our Leukocyte Dynamics Lab ran by Leo M. Carlin to work on a multi-disciplinary project investigating the role and regulation of neutrophils in liver disease 👉Find out more and apply here: crukscotlandinstitute.ac.uk/careers/postdo…

Delighted to have been awarded a Springboard award by Academy of Medical Sciences to investigate the role of cancer associated fibroblast in immunotherapy resistance in HCC. Thanks to all my collaborators who make the work possible Ankur Sharma Helen Reeves Derek A Mann HUNTER: Hepatocellular Carcinoma Expediter Network

Today is world liver day 🌍 To mark the occasion the NIHR Newcastle Biomedical Research Centre @NIHRCRN_NENCumb Liver Disease Theme have highlighted some of the amazing work (if I do say so myself) going on at Newcastle University HUNTER: Hepatocellular Carcinoma Expediter Network livingwithlivercancer.co.uk/news-and-event…

I’ve made the jump to bluesky. Follow me here for our research updates bsky.app/profile/jlesli…

Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease