Happy to share authors.elsevier.com/sd/article/S10… Cell Press Immunity. CD4 T cells contribute to protection against #TB in a reinfection macaque model by interacting with CD8s to generate an anti-inflammatory granuloma environment. Kudos to first authors Sharie Ganchua and @joshuabromley21

Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Happy to have made a contribution to this excellent work by @OwenKLeddy and Bryson Lab. A super and cool approach to identifying TB vaccine candidates.

Thanks Bryson Lab for the tweetorial as always and the cool science!

What a week! One word to summarise the 7th Global Forum on TB Vaccines: #Optimism. The prospect of imminent adolescent & adult TB vaccines gives the global TB community hope for a future without #TB. Sentiments also shared by Sir Jeremy Farrar, WHO Chief Scientist. #7GF #EndTB

Check out new story with collaborators at TGEN. CRESTA, a new approach to identifying Mtb antigen specific T cells with high order of magnitude. Happy to have played a role.

Congratulations Rachel Tanner 💉 and colleagues

The optimism of controlling TB is dampened by uncertainty of NIH funding. TB research has come from so far, with sparse but significant successes. It is sad to see all that likely go to the drain and plenty of careers ruined. #KeystoneTBsymposium

Significant progress in TB control efforts over recent years. The future of these achievements shouldn’t be in the balance because of uncertainty in funding modalities.

I draw lots of inspiration from from advocates - people who living with the conditions and diseases that keep scientists awake trying to control. Rebecca Denison’s presentation at CROI today was powerful today at #CROI2025

Our combination immunotherapy clinical trial shows some promise towards ART-free HIV control. This offers hope for a HUV cure. Great collaboration between the community and multisector stakeholders. Tom Kariuki, PhD Denis Chopera Ragon Institute Victoria Kasprowicz UCL Division of Infection & Immunity

Positive and uplifting progress. Congratulations Prof. Thumbi Ndung'u and entire study team and participants

Recent Findings show that early T cells at the site of PPD antigen challenge are not Mtb-specific. Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones biorxiv.org/content/10.110…

Mycobacterium tuberculosis suppresses protective Th17 responses during infection through multiple mechanisms biorxiv.org/content/10.110… #biorxiv_immuno

It was my pleasure to be interviewed by The Immunology in Africa Podcast for this episode of Immunology to TB. Here I share my journey as a scientist and our contributions to TB vaccine development.

Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design bit.ly/44cVTYB

The fourth episode in our #TBImmunologySeries ft. Solomon Jauro 🇳🇬🇿🇦🇬🇧🇺🇸, a veterinarian & postdoc at University of Pittsburgh, where he studies #TB in #macaque models. Listen here: Spotify: bit.ly/4kMiDVp Amazon Music: bit.ly/3SZByzP Apple Podcasts: bit.ly/3HK5VYF

The fifth episode in our #TBImmunologySeries ft. Anele Gela, a Research Officer at South African Tuberculosis Vaccine Initiative, UCT , where he studies host determinants of protective immunity against #tuberculosis. #Immunology #Vaccines #TB #Tuberculosis #SciComm #GlobalHealth #PublicHealth #Immunity

Spatial profiling reveals TREM2+ macrophages as central to Mycobacterium tuberculosis pathogenesis in human pulmonary tuberculosis biorxiv.org/content/10.110… #biorxiv_immuno

Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages biorxiv.org/content/10.110…