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The FDA has approved the drug lenacapavir as a twice-yearly injection to prevent HIV. Clinical trials showed that 99.9% of participants who received the drug remained HIV negative. CBS News' Jonathan LaPook, M.D explains what this breakthrough means.

Incredible 4-hour deep dive on modern antiretrovirals. Well worth the listen today. We’ve come a long way from the early days of AZT and tenofovir. An IAVI vaccine is the next milestone, and we’re closer than ever.

Some things worth working on don’t make much money. What people choose to work on determines what new technologies are made. This one was so worth it, grandkids proud level. Thank you for your service. 🫡

Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA) Why is it such a big deal? When trialled (in women in South Africa and Uganda) there were 0 HIV infections 🧵

Japan has more than doubled its foreign aid budget in just five years— Foreign aid has saved and improved millions of lives through health programs, food aid, and humanitarian assistance. Several countries — including the United States and the United Kingdom — have announced

Alex Cohen World Health Organization (WHO) My personal (not co-authors/WHO) view on projects that would get funded: I think some of the work Jacob Trefethen has highlighted (eg, here: blog.jacobtrefethen.com/vaccines/) would be more likely to get done if social value was systematically assessed in the way the guidance recommends.

Statins and GLP-1s both sort of boggle my mind. (As do PCSK9 inhibitors.)

I sat down with Samuel Hughes and Ben Southwood to discuss THE GREAT DOWNZONING. Why did the world ban housebuilding in a matter of years in the 20th Century – and what can this tell us about changing course? Samuel (Samuel Hughes) explains why zoning was so popular in cities as

It’s interesting to me that when we look for guidance on big topics like, ”What does it mean to be a good person?”, or “What makes for a meaningful, worthwhile life?”, many of the canonical texts we regularly refer to are very old. Nicomachean Ethics, Meditations and the Bible,

Epic

✍️ New article: The end of tuberculosis that wasn’t In the 1980s, many thought tuberculosis (TB) was on the path to elimination. In reality, more were dying from the disease than ever. In a new article, Hannah Ritchie and Fiona Spooner cover the reality of tuberculosis in the

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Finished listening to this in the AIDS Memorial Grove while baby napped on me in his carrier. Really enjoyed it, I love when people care about all the tiny details of enormously important things!

5 medical breakthroughs from June (🧵) 1. Approval of an extremely effective, twice-yearly HIV preventative It's called Lenacapavir, and it gave rise to one of the most striking figures in clinical trial history nejm.org/doi/10.1056/NE…