“It happened, therefore it can happen again: this is the core of what we have to say.” ~ Primo Levi from “The Drowned and The Saved” thanks to Philip Gourevitch

While we are getting used to the results of ultra-polygenicity, they remain difficult to conceptualize. i.e., why prioritize research of one molecular pathway if they are all involved? One hypothesis is that there are meta-functions of genes that we have not yet discovered.

You are correct; we have learned this from families. It just needed a formal analysis with lots of data.

Congrats !

Great but can you re-introduce the color coding identifying the type of variant : LoF versus missense? That was super practical !

Esta es la "infraestructura" en la que nadie está invirtiendo. (Ni con una pandemia encima). Ese es todo el tweet.

Just wanted to share with the world how immensely proud I am that Ania Fiksinski brilliantly defended her #PhD thesis today. Congratulations Dr Fiksinski 🎓. You have impressed us all. Time to celebrate 🥳👏💃🕺 #22q11DS #Psychiatrygenetics #schizophrenia #autism

Exome sequencing finds a genetic cause of cerebral palsy in 32.7% of pediatric patients and 10.5% of adults! 229 genes implicated in CP from our study of 1,526 patients. ja.ma/3oGVVQO JAMA JAMA Network GeneDx Geisinger ADMI @GeisingerRads

Molecular Diagnostic Yield of Exome Sequencing in Patients With Cerebral Palsy | Genetics and Genomics | JAMA | JAMA Network jamanetwork.com/journals/jama/…

I'm so proud of my team, and humbled and grateful for the opportunity to contribute to our understanding of 3q29 deletion syndrome: nature.com/articles/s4143…

Study is out! High-confidence LoF mutations in a large proportion of ASD-genes show moderate relative risk for ASD and are observed in unaffected individuals. Yes, these variants are deleterious, but we overestimate their impact in the clinic!

Rare CNV carriers may help us understand not only rare isolated syndromes, but also interrelated disorders and interaction between rare and common variants in shaping brain and disease. See how in the ENIGMA-CNV & 22q11.2 WGs’ review out today in HBM: onlinelibrary.wiley.com/doi/full/10.10…

There are no autism-specific genes, just brain genes, a #SpectrumViewpoint by David H Ledbetter (he/him) and Scott Myers bit.ly/no_autism_spec…

.Emilie Wigdor: Recent work has shown: - common variants contribute risk for neurodevelopmental disorders (work by Mari Niemi) - years of schooling, intelligence, and schizophrenia are genetically correlated with risk for NDDs - sig enrichment of rare, inherited variants #GRD21

#JobAlert: Are you ready to tackle brain function and risk for psychiatric disorders using large-scale sequencing, neuroimaging, and cognitive datasets! Paul Thompson, Genes to Mental Health Network, Armin Raznahan, Genes to Mental Health Network

Our new review in Current Opinion in Genetics & Development: Structural and functional brain alterations in #CNVs overlap with those found in idiopathic #psychiatric conditions but effect sizes are 2 to 5 fold larger @Winkytheelf Sebastien Jacquemont @meetkd007 sciencedirect.com/science/articl…

Neuroimaging of large effect-size genetic risk for neuropsychiatric disorders is gaining traction! This robust effect and can be leveraged to link molecular function to large-scale brain networks.

Interview with Sebastien Jacquemont about our last paper in Brain "Dissecting autism and schizophrenia through neuroimaging genomics" 🧠🧬academic.oup.com/brain/advance-…

Monumental work by an awesome student !!!!

Clara Moreau @pierre_bellec Sebastien Jacquemont Annabelle Harvey Kuldeep Kumar Paul Thompson @s_urchs Thomas Bourgeron Huguet Guillaume @Winkytheelf Laura Schultz, PhD Congratulations Clara ! 🎉 You’re on fire 🔥🤘