Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359 disq.us/t/3u1mvpv

Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890–Fit for Translation? pubs.acs.org/doi/10.1021/ac…

Glad to present my poster on ligand-induced G protein coupling bias at the adenosine A2B receptor right now at the #ECIGPCR symposium (Poster #75) - Happy to see you around!

It's out! Big thanks to everyone involved! agmueller.unibonn Xavier Deupi Ramon Guixà-González sciencedirect.com/science/articl…

Happy to share our new publication on the G protein coupling of the adenosine A2B receptor! pubs.acs.org/doi/full/10.10…

Irreversible Antagonists for the Adenosine A2B Receptor mdpi.com/1674900 #mdpimolecules via Molecules MDPI

Happy to share my just-published review article on the use of the Gq/11 inhibitors YM-254809 and FR900359 as tool compounds in GPCR research! pubs.acs.org/doi/epdf/10.10…

Targeted protein degradation #TPD of HDACs by hydrophobically tagged inhibitors. What an effort by my PhD student Felix. From solution- and solid-phase synthesis to biochemical and cellular assays, Felix did everything! Now online in ACS Med. Chem. Lett. pubs.acs.org/doi/10.1021/ac…

Are you interested in #GPCR / #Gprotein signaling and #biosensor development? Then please apply for this open #PostDoc position in my new Emmy Noether Research Group Philipps-Universität! stellenangebote.uni-marburg.de/jobposting/9f7… #newPI