Excited to share my PhD story, out in Developmental Cell today: sciencedirect.com/science/articl…! We show that Nrf2-driven induction of the pentose phosphate pathway stimulates liver regeneration after injury. Thanks to Andy Cox, Mark Dawson, Cox Lab and The Dawson Lab members! Incoming 🧵1/9

We’re hiring 2x bioinformatics/computational biology RA’s in Mark Dawson’s lab in Melbourne! You’ll be working on all things single-cell and harnessing the power of our SPLINTR lineage tracing tool! careers.petermac.org/job/MELBOURNE-… Please share with your network☺️

Arjun Raj Reminds me of what Brenner said about differentiation in Loose Ends (Current Biology). cell.com/current-biolog…

me on my way to annoy my lab mates instead of writing this abstract

What a PERFFect day to share our new preprint! With Tsion Abay #BobStickels Meril Takizawa @ChaligneRonan and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Stellar 2024 Lab retreat with the best people! Ready for the year ahead! ⭐️ #DawsonOpen🎾 #unitedinnovation #boundlessdiscovery #bigimpact

When the results you've been excited about for 2 years turn out to be an artifact

How to pick a problem. Today in Cell. 1/53 cell.com/cell/fulltext/…

Our latest paper from ⁦The Dawson Lab⁩ - huge congratulations to ⁦Henrietta Holze⁩ & ⁦Dane Vassiliadis⁩ who led this work - hope the lineage tracing / barcoding community find this helpful cell.com/cell-reports-m…

Proud to see our paper describing BARtab and bartools, two integrated software tools for the analysis of synthetic cellular barcodes is now published Cell Reports Methods! We hope the community finds this work useful. cell.com/cell-reports-m…

So good to finally see this out in all its glory. I remember Charlie Bell first telling me about this system on the drive down to lab retreat in my first few weeks in the lab, and it was beautiful to see the story develop. Bravo, Charlie!

Last month, the Dawson Lab celebrated our 10th year in action! 🎉 It was a wonderful day of laughs, catching up, and reflecting on just how far we’ve come over the last decade. What a great looking group! See ya in 5 years! 🥂

Dr Jamie Kuzich (Jamie Kuzich) from The Dawson Lab has received the ASH 2024 Global #Research Award - one of just of 11 awarded to early career investigators from around the globe. Watch 👇Read more: petermac.org/about-us/news-… #bloodcancer #hematology #haematology

Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in Blood Journal, we’ve discovered an intriguing mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL. Thread👇

Gonna get a tattoo on my chest that reads "just because a result is statistically significant does not mean it is biologically significant" & a matching tattoo on my back that reads "just because a result is biologically significant does not mean it is statistically significant"

7:30: Declare big day of writing 8:00-17:00: Fail to write 17:30: Declare big day of writing tomorrow

Bridging RT v systemic tx retrospective before axi-cel #ASH24: - 98 pts, 35 RT bridging alone - CR 85% RT, 71% chemo (not significant) - 1-yr PFS 75% RT, 49% chemo (significant) - MV model PFS: improved PFS (HR 0.41) with RT alone Time for a randomized trial. #lymsm

CART could have it ALL. Obe-cel results NEJM: 👉127 pts 👉complete remission 55% 👉median event-free survival 12 months 👉1-year survival 65% 👉severe CRS/ICANS in 2% and 7% 👉survival curve plateau but limited follow-up 👉high tumor burden still a challenge Congrats

Glofi+R-CHOP/R-polaCHP. I really like this study schema, allowed for short Dx to Tx interval to actually get a high risk group in study. #lymsm #ASH24