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36 datasets, 26 protocols, 1.7 million harmonized cells! First edition Human Neural Organoid Cell Atlas. Important work from ZhiSong He 何志嵩 Jonas (josch1@bsky) Leander Dony Treutlein lab Fabian Theis. Strong community effort Sergiu P. Pasca Giorgia Quadrato. #organoids D-BSSE, ETH Zurich Institute of Human Biology

Spatial transcriptomics in adult flies! I feel rejuvenated by finding localised mRNAs in gigantic flight muscles, 20 years after studying bicoid mRNA in oocytes. Fantastic collaboration with @steinaerts Jasper Janssens @PierreMangeol & co-thank you all! biorxiv.org/content/10.110…

Human brain atlas papers by Kimberly Siletti Alejandro Mossi Kawai Ernest Arenas Emelie Braun Miri Danan Gotthold Rebecca Hodge Trygve Bakken Ed Lein Lars Borm Elin Vinsland Erik Sundström and many others. With a stunning double cover illustration by Ivana Kapustová

Extremely happy to be awarded an #ERCSyG grant ETH Zurich D-BSSE, ETH Zurich together with Elly Tanaka Elly Tanaka IMP & Kevin Briggman MPI for Neurobiology of Behavior – caesar! In #AxoBrain, we will map cell types, architecture & circuits of the axolotl brain and explore its amazing regenerative capacity!

We are recruiting! If you are interested in neuronal evolution or neuronal circuits or you just enjoy generating new tools in different bugs, please consider applying. If not, please retweet :-) More information by email or DM. You can apply here: emploi.cnrs.fr/Offres/CDD/UMR…

Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: nature.com/articles/s4158…. Highlights below: [1/n]

Very happy to see my final PhD paper on designing synthetic enhancers for selected tissues in vivo using #AI out in nature 🥳 Big thanks to Alexander Stark and whole StarkLab , as well as collaborators in Eileen Furlong lab! Check out our thread below for more details 👇

Happy to announce the first paper of my postdoc in the Treutlein lab! A fun collaboration with Hsiu-Chuan Lin where we investigated how morphogen signaling pathways can be used to increase the diversity of TF-induced neurons. Check the paper here: t.ly/XfJvk!

Thrilled to share my PhD work in the Treutlein lab & Gray Camp! In this 🚨preprint🚨, we present an integrated perspective on how morphogens impact early human neural organoid development: biorxiv.org/content/10.110… Tweetorial landing in 3, 2, 1...

How much of our genome is 'noise' and how much is actually functional? In the de Boer lab's latest paper (along with The Dark Matter Project) we aim to uncover the truth behind this long standing debate! 1/ rdcu.be/dAv4y nature.com/articles/s4158…

Do you love big data and the brain? We have #ScienceJobs for you! In Drosophila there are >11,000 cell types that define the circuit structure of the connectome – but we don't know their molecular identity. Integrating connectomes and transcriptomes would be revolutionary. RT 1/3

Very excited to announce our new preprint together with Nikolai Hecker! Dive into our findings on the conserved regulatory codes shaping cell identity across species. 🧬 [1/n] biorxiv.org/content/10.110…

The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory? We move towards this answer, predicting transmitters from EM! w/Nils Eckstein, vid Amy Robinson Sterling, 1/n Published Cell: cell.com/cell/fulltext/…

Last week I got awarded the ASL - Academische Stichting Leuven award for Biomedical Sciences KU Leuven for my PhD research 🪰🧠. Very proud and humbled to receive this award and eternally gratefull to all the amazing scientists who I was able to work with, especially my mentor @steinaerts! Thanks!!🙏🙏

Happy to share CREsted, our latest package on enhancer modeling! CREsted allows for training sequence-based deep learning models from scATAC-seq data, enhancer decoding and enhancer design through a variety of methods. Check out the GitHub here: github.com/aertslab/CREst…. [1/9]

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to Sven Dorkenwald and Philipp Schlegel, first authors of the connectome papers, Murthy Lab Sebastian Seung for establishing #flywire to make this possible and Davi Bock for birthing this dataset.

Our ChromBPNet preprint out! Huge congrats to Anusri Pampari! This was quite a slog for both of us but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Link in the next tweet. Bluetorial coming soon .. 1/