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Thinner is not always better: Optimising cryo lamellae for subtomogram averaging biorxiv.org/cgi/content/sh… #bioRxiv

Cryo-electron tomography is a hugely promising tool in visual proteomics — if researchers can work out what they are seeing go.nature.com/3ZotjQa

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Our mapping of the cellular protein #interactome with unprecedented depth is now published nature. Leaps in robust #proteomics and analytic workflows enabled us to perform over 4.000 pull-downs in yeast unraveling the social and structural aspects leveraging #alphafold multimer.

Our team at #CZImagingInstitute is excited to share the #CryoET Data Portal beta release. With over 13,000 tomograms, it’s the start of what we hope will be a large, open-access portal of high-quality, standardized & annotated cryo-ET data. bit.ly/3T9sZ6D

My grandfather built motors that powered big machines. In a lab not so different from his workshop, my colleagues and I uncovered the assembly of the bacterial motor. Today, this discovery has been published in Nature Microbiology #MolecularNodes #Discovery nature.com/articles/s4156…

How to optimize samples to study subcellular architecture and structures of biomolecules in situ by #cryoET? 💡Novel insights on optimal lamellae thickness and extend of structural damage in cryo-FIB milling by M. W. Tuijtel & coworkers published in Science Advances! #biophysics

We are excited to announce the publication of high confidence 3D template matching for #cryoET Hummer Lab Beck Laboratory Jan Philipp Kreysing @geissler_katha @s_l_schaefer @pc_hoffmann Max Planck Institute of Biophysics CZI Science Paper's link: nature.com/articles/s4146… See it in action in our short video!

Our latest submission to bioRxiv is now online. biorxiv.org/content/10.110… Huge thanks to all authors Lucas Defelipe @SkruznyMichal Dynamics of viral Structures Roland Thuenauer @katharinchen5 Osvaldo Burastero Isabel Bento and contributors involved in this collaborative work.

Crystallography vs cryoEM

Having a great time at #EMBOautophagy24 ! Great discussions about autophagosome biogenesis, lipid transfer and autophagic cargo!

Great opportunity for a PhD using exciting methods in beautiful Hamburg!

Doing good science is 90% finding a science buddy to constantly talk to about the project.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

#ProgramAlert have you seen our updated program?? This annual meeting will be fantastic!! Are you going to miss it? Register here: forms.office.com/r/vXS654upEXTh… you Biochemical Society and The Company of Biologists for your support! Patricia Boya The AIM Center AutophagyUK Network SEFAGIA (Sociedad Española de Autofagia) Autophagy India Network (AIN)

Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x tinyurl.com/c7szhtfa

Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. biorxiv.org/content/10.110… Muscle mito nanotunnels 1/3🧵

CryoEM structure of the human uromodulin filaments (PDB code: 9NU3) #scivis #molecularart Dzine 3D Protein Imaging behance.net/gallery/226765…

Mechanism of bridge-type phospholipid transfer by Atg2 for autophagosome biogenesis biorxiv.org/content/10.110…