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How do cells maintain lysosomal integrity under stress? In our latest review, we break down five levels of lysosome quality control—regulation, reformation, repair, removal, and replacement. Summarized by our awesome postdoc Danielle Henn doi.org/10.1080/155486…

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum; hopefully a useful concept😀. Snapshot below and Open Access here: embopress.org/doi/full/10.10…

Cellular homeostatic responses to lysosomal damage dlvr.it/TJSX1c

Lysosomal storage disease is beatable! 💪 Join us today at 12 PM EST for an exciting talk by Dr. Ming Li Ming Li Lab@Umich on lysosomal quality control & lysosomal storage disease. Aging Institute at the University of Pittsburgh PittDeptofMed

Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain Aakriti Jain and amazing collaborators Rushika M. Perera, Guido Bommer, Charly Craik and James Olzmann: science.org/doi/10.1126/sc…

Hormesis is everywhere, but particularly important on lysosomes. In this comment, I try to define 'Lysohormesis' as a mechanism and strategy for health benefits. Mild lysosomal stress is emerging as a way to avoid or delay many age-related issues. nature.com/articles/s4155…

Congratulations to HHMI Investigator David R. Liu (David R. Liu) on receiving the 2025 Breakthrough Prize (Breakthrough) in Life Sciences! He is recognized for developing base editing and prime editing: two breakthrough gene-editing technologies that enable the correction or

Check out our latest Comment in Nature Cell Biology on #autophagy (how cells of your body recycle damaged material). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea. SAHMRI Uni of Adelaide nature.com/articles/s4155…

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell cell.com/cell/fulltext/…

When protein quality control breaks down, aging speeds up. Tomorrow, Dr. Ling Qi decodes SEL1L-HRD1 ERAD in his talk at the Aging Institute: “Unlock the Secrecy of SEL1L-HRD1 ERAD: One Mouse and Human at a Time” 12:00 - 1:00 pm 5th Floor Conference Room, Bridgeside Point 1

Congrats to Nan , Jingzhi , Meiqin , and all co-authors for the publication of LysoH2 story . SLC7A11 is an unconventional H+ transporter in lysosomes: Cell cell.com/cell/fulltext/…

Excited to share our latest review "Lysosomal Repair in Health and Disease". We summarized how cells repair lysosomal damage via 4 distinct strategies and discussed the implications for aging, neurodegeneration, cancer, infection, and more. Open access: onlinelibrary.wiley.com/doi/10.1002/jc…

Thrilled to have our story on the regulation of lysosomal lipids out in Cell Metabolism! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure HHMI UW–Madison Biochem

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by amalia megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Tweetorial! 1/9 pnas.org/doi/10.1073/pn…

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/sc…

Organelles share the load | Science science.org/doi/10.1126/sc…

Left by the tides | Pitt Med Magazine | University of Pittsburgh. A nice piece on our earlier work on identifying 12h rhythms in ‘free-living” humans. pittmed.pitt.edu/news/12-hour-b…

New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN

New online! V-ATPase assembly at leaky lysosomes bit.ly/4ln0IVv