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Sequence-Dependent Conformational Transitions of Disordered Proteins During Condensation biorxiv.org/cgi/content/sh… #biorxiv_biophys

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Great to participate in this led by Hyman Lab, Simon Alberti, Jeetain Mittal and w/ Ayala Lab, Titus Franzmann probing how cysteine oxidation aggregates TDP-43 Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates biorxiv.org/content/10.110…

Noah Wake, Shuo-Lin Weng, Tongyin Zheng and Jeetain Mittal and my lab find R-R and polar residues contacts including Q contribute to FUS phase separation. Specific polar residue positions, not just residue type, regulate liquid-to-solid change #Friday_FUS biorxiv.org/content/10.110…

Excited to see beautiful manuscript led by Ushnish Rana & Kevin w @iAmAllAdhesion Mack Walls Jose L. Avalos & AZP out in Nature Chemistry (...after 5 mo. copyediting :( rdcu.be/dzddw Also see related co-submission by Matthew C. Good & Jeetain Mittal rdcu.be/dxP4r

Thrilled to finally announce our work on the selectivity of disordered protein condensation in Nature Chemistry. Great collaboration with Jeetain Mittal Led by Rachel Welles and Kandarp Sojitra. rdcu.be/dxP4r. See related work by Brangwynne lab rdcu.be/dzddw

Excited to share a new preprint from Jeetain Mittal lab led by our talented graduate student - Busra Ozguney. We used atomistic MD simulations to explore how RNA modifies the conformational landscape and intradomain stability of TDP-43 tandem RRMs. biorxiv.org/content/10.110…

Excited to share our recent computational work from Jeetain Mittal's lab in Nature Communications (nature.com/articles/s4146……), where we show how material properties of condensates are encoded in a disordered protein sequence and can be predicted from dilute phase conformations.

It's time for #FridayFacultySpotlight with Dr. David Powers 💡 Dr. Powers is a 2020 recipient of the Sloan Foundation Chemistry fellowship and the 2019 U.S. National Science Foundation CAREER Award! 🥇 We're so grateful for all Dr. Powers does for the department! 👍

Our study of tau phase separation in the context of chromatin is now out Communications Biology Congratulations to authors Lannah Abasi, Nesreen, Manasi Movva, Amar Deep and big thanks to Kevin Corbett lab for the collaboration! nature.com/articles/s4200…

Excited to share our work with The Libich Lab that recently got published in J. Am. Chem. Soc.. Using NMR and MD we provide the molecular picture of EWS LCD phase separation and highlight the diversity within FET family. Special thanks to Jeetain Mittal David Libich Courtney N. Johnson, Ph.D.

A synopsis of the recent work from Prof. Jeetain Mittal's group at Texas A&M, in collaboration with Prof. Arash Nikoubashman at PoL and IPF - 'Charging Up: Identifying the Sequence-determinants of Condensate Material Properties' physics-of-life.tu-dresden.de/news/2024/03/1…

It was a pleasure to present my postdoctoral research work from Jeetain Mittal lab at #DiscoverBMB 2024 in San Antonio, TX. Many thanks to ASBMB for the opportunity and travel award to present my work !!

Expanding the molecular language of protein liquid–liquid phase separation: nature.com/articles/s4155…

Happy to announce that our work uncovering the relationship between protein sequence, phase behavior and material properties in collaboration with the Kiick Research Group and the Schuster Lab is now published in Nature Chemistry. nature.com/articles/s4155…

Happy to share our latest preprint on the phase separation mechanisms of MBD2 and MBD3 from the methyl-CpG-binding domain family. This exciting work is a collaboration between Jeetain Mittal and Alaji Bah groups. biorxiv.org/content/10.110…

Happy to share a new preprint from Jeetain Mittal lab where we investigated the role of N17-polyQ (interdomain) interactions on the monomeric ensemble and oligomerization of Huntingtin Exon 1 using extensive, brute-force and REMD simulations. Tien Phan doi.org/10.1101/2024.0…

Amazing work by Jeetain Mittal and Nicolas Lux Fawzi labs! The conserved, hydrophobic α-helix in TDP-43’s IDR favors tetrameric helix-helix interactions. Interesting insights into TDP-43 oligomerization & implications for aggregate & amyloid initiation! biorxiv.org/content/10.110…

Mittal Jeetain Mittal, Good Matthew C. Good, and their co-workers report the determinants that enable disordered protein assembly into discrete condensed phases nature.com/articles/s4155…

Kiick Kiick Research Group, Schuster Rutgers University and Mittal Jeetain Mittal and co-workers report on expanding the molecular language of protein liquid–liquid phase separation nature.com/articles/s4155…