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CFF will invest 500 million dollar to find a way to cure CF. #NACFC

New from Dr. Jeffrey Beekman's lab! Forskolin-induced swelling of intestinal #organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations. bit.ly/2QG2UvN

*NEW* today in Cell Stem Cell! Patient-derived #organoids predict chemoradiation responses of locally advanced rectal cancer. Hans Clevers 👉 bit.ly/2s7PMp9

This is the first time #Organoids modelled human disease. In a seminal 2013 Nature Medicine paper, Joanna Dekkers at UMC Utrecht International. modelled #CysticFibrosis with intestinal organoids, and set the scene for their role in #DrugDiscovery today 💊 #JournalClub nature.com/articles/nm.32…

#organoids #cysticfibrosis

Exciting times! We are done recruiting over 500 people with CF and selecting drug responsive organoids is well underway! HIT-CF is on fire! prnewswire.com/news-releases/…

A common gut microbe secretes a carcinogen. A publication today in @nature by Hans Clevers The Clevers Lab and Ruben Van Boxtel PrinsesMáximaCentrum, @Cayetanopm , Jens Puschhof and Axel Rosendahl Huber. hubrecht.eu/a-common-gut-m…

This not only involves matters on patient data but also patient derived biomaterials such as living cells. Institutions need to realize that this requires long term investments that cannot be covered by short term project grants. nature.com/articles/s4159…

Responsible use of organoids in precision medicine: the need for active participant involvement A Spotlight by Mike Lensink @JongsmaKr Sarah Boers Jacquelien Noordhoek Jeffrey Beekman & Annelien Bredenoord dev.biologists.org/content/147/7/…

Towards more treatments for everyone with cystic fibrosis. prnewswire.com/news-releases/…

bioRxiv viewer disq.us/t/3un2gx9 Great imaging - game changer

medrxiv viewer disq.us/t/3umrqvq Happy to share our latest work showing strong relations between organoid CFTR function and long term clinical disease in cystic fibrosis.

The balance between kinase and phosphatase activity provides a control point for gene expression that can be exploited to inhibit tumorigenesis #cancerresearch bit.ly/3hz3Dwq

For those interested in airway cell ultrastructure in 3D with or without sars-cov2. Check out this paper from the Kapitein lab. Still needs peer review but the 3D imaging doesn’t get better than this I think. biorxiv.org/content/10.110…

#organoids associate with long term term disease progression in people with #cysticfibrosis. Better than any other potential predictive factor we tested. Big thanks to all people sharing tissues, all Dutch Cf centers and especially the whole #UMCU CF team. erj.ersjournals.com/content/early/…

Are you a PhD student or post-doc and would you like to make a #career switch to #science #management? Please check out this great #jobopportunity at our department: Translational Neuroscience of the UMC Utrecht. lnkd.in/e_kSKYkp

#194 Taaislijmziekte te lijf met minidarmpjes nrc.nl/nieuws/2022/06… via NRC

Thanks to Gimano Amatngalim and the team! Great technology for studying respiratory disease such as cystic fibrosis in 2D-ALI derived nasal organoids. Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia life-science-alliance.org/content/5/12/e…

Our friends at Emily's Entourage are hosting a town hall on gene-based therapy to share information about these therapies and answer any questions you have! The event is free and open to all, but registration in advance is required. classy.org/event/gene-the…